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FLASH GENE
Symbol SPIRE2 contributors: SGE/npt - updated : 22-03-2014
HGNC name spire homolog 2 (Drosophila)
HGNC id 30623
Location 16q24.3      Physical location : 89.894.906 - 89.937.727
Synonym symbol(s) Spir-2, KIAA1832, MGC117166
DNA
TYPE functioning gene
STRUCTURE 42.82 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3249 - 714 - Nagase (2001)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousbrain    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one KIND domain
  • three WH2 domains
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • spire family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament
  • SPIRE1, SPIRE2, and COBL can synergize with other actin regulators
  • involved in vesicle transport processes providing a new link between actin organization and intracellular transport
  • mediated actin-microtubule interactions and has important roles in membrane transport (Ducka 2010)
  • SPIRE1 and SPIRE2 cooperate with Formin-2 (FMN2) to nucleate actin filaments
  • COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to actin monomers via the WH2 domain
  • SPIRE1, SPIRE2 cooperate with FMN2 to drive asymmetric oocyte division
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS