basic FUNCTION
| acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament |
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SPIRE1, SPIRE2, and COBL can synergize with other actin regulators  |
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involved in vesicle transport processes providing a new link between actin organization and intracellular transport |
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mediated actin-microtubule interactions and has important roles in membrane transport (Ducka 2010) |
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SPIRE1 and SPIRE2 cooperate with Formin-2 (FMN2) to nucleate actin filaments  |
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COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains  |