SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton
|
basic FUNCTION
| involved in actin organization and in filament nucleation |
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involved in vesicle transport processes |
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SPIRE1, SPIRE2, and COBL can synergize with other actin regulators |
|
mediated actin-microtubule interactions and has important roles in membrane transport (Ducka 2010) |
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SPIRE1 and SPIRE2 cooperate with Formin-2 (FMN2) to nucleate actin filaments |
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COBL and SPIRE1, SPIRE2 display different functions by selecting different sets of the multifunctional properties of WH2 domains |
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in mammalian oocytes, three actin binding proteins, FMN2, SPIRE1, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization |