basic FUNCTION
| inhibitor of hepatocyte growth factor activator (HGFAC) |
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involved in regulation of proteolytic activation of HGF in injured tissues |
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important role in maintaining the integrity of basement membrane most likely by regulating extracellular proteolytic activities during placental development |
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has critical roles in the regulated keratinization of the epidermis and hair development |
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Kunitz-type serine protease inhibitor that has a broad inhibitory spectrum against serine proteases |
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plays an important role in maintaining colonic epithelium integrity |
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is critically required for the cell surface localization of ST14 in trophoblasts, and, in the absence of SPINT1, physiological activation of PRSS8 and other protease(s) initiated by cell surface matriptase may be impaired |
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essential for branching morphogenesis in the chorioallantoic placenta and lack of SPINT1 function may result in placental failure |
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membrane-bound serine protease inhibitor expressed on the surface of epithelial cells |
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has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface serine protease inhibitors and protection from carcinogenic stimuli |
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SPINT1, SPINT2 influence proliferation and cell fate of |
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neural progenitor cells (NPCs) and their expression levels are linked to BMP signaling |
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SPINT1 regulates the activity of activated ST14, whereas SPINT2 has an essential role in regulating PRSS8-dependent ST14 zymogen activation |