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FLASH GENE
Symbol SPINK7 contributors: SGE - updated : 03-05-2008
HGNC name serine peptidase inhibitor, Kazal type 7 (putative)
HGNC id 24643
Location 5q33.1      Physical location : 147.691.989 - 147.695.479
Synonym name esophagus cancer-related gene-2
Synonym symbol(s) ECRG2, ECG2, MGC133105, MGC133106
DNA
TYPE functioning gene
STRUCTURE 3.49 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 566 9.2 85 - Cheng (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
 mouth    
 pharynx    
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Kazal-like domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized to centrosomes during interphase and kinetochores during mitosis
  • secreted
  • basic FUNCTION
  • acting as a serine protease inhibitor
  • contributes to chromosome stability via regulating centrosome amplification and spindle assembly checkpoint
  • participating in centrosome amplification in a TP53-dependent manner
  • playing an important role for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in cancers
  • regulates cell migration/invasion through PLAUR/beta1 integrins pathway (Cheng 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MT2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS