Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SPINK6 contributors: mct - updated : 30-03-2011
HGNC name serine peptidase inhibitor, Kazal type 6
HGNC id 29486
Location 5q32      Physical location : 147.582.356 - 147.594.699
Synonym symbol(s) BUSI2, UNQ844, UNQ844/PRO1782, MGC21394
DNA
TYPE functioning gene
STRUCTURE 12.30 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 690 - 80 - 2010 20667819
- - 610 - 80 - 2010 20667819
EXPRESSION
Rna function mRNA was detected to be expressed at low levels in several tissues and was induced during keratinocyte differentiation
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   moderately
Skin/Tegumentskin   predominantly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermisstratum granulosum  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentepidermal secretory cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • only one typical Kazal domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a serine-type endopeptidase inhibitor
  • potentially plays a role in modulating the activity of KLKs in human skin
  • inhibits KLK5, KLK7, KLK14 but not KLK8
  • potent inhibitor of distinct KLKs members
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • selective inhibitor of KLKs in the skin
  • cell & other
    REGULATION
    induced by during keratinocyte differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in lesions of atopic dermatitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS