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FLASH GENE

Symbol

SPINK2

contributors: mct/npt - updated : 24-08-2022

HGNC name	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
HGNC id	11245

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPGF29 spermatogenic failure 29
Location	4q12      Physical location : 57.676.033 - 57.687.893
Synonym name	acrosin-trypsin inhibitor
	epididymis tissue protein Li 172
Synonym symbol(s)	HUSI-II

DNA

TYPE	functioning gene
STRUCTURE	12.01 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - D4S1619 - SPINK2 - D4S1600 - D4S2987 - D4S416 - D4S409 - D4S392 - cen
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001271718 4 - 722 NP_001258647 - 134 - 2019 31391482 NM_021114 4 - 572 NP_066937 - 84 - 2019 31391482 NM_001271721 4 - 637 NP_001258650 - 88 - 2019 31391482 NM_001271720 4 - 677 NP_001258649 - 119 - 2019 31391482 NM_001271722 2 - 568 NP_001258651 - 134 - 2019 31391482 NM_001271719 3 - 682 NP_001258648 - 103 - 2019 31391482

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate         male system testis     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

storage

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	inhibitor from seminal plasma that may therefore be seen as the natural antagonist of the sperm protease acrosin
	can serve as a scaffold to generate therapeutic molecules against target proteins with groove structures

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RARRES1 interacts with SPINK2 in NT2/D1 testicular carcinoma cells and interaction between TIG1 and SPINK2 plays an important role in the inhibition of testicular cancer cell EMT

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF29

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in acute myeloid leukemia tumoral     --low   in testicular cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene	for celiac disease susceptibility
Marker	could be a biomarker for diagnosis and prognosis of AML
Therapy target

ANIMAL & CELL MODELS