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FLASH GENE
Symbol SPINK2 contributors: mct/npt - updated : 22-08-2008
HGNC name serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
HGNC id 11245
Location 4q12      Physical location : 57.676.033 - 57.687.893
Synonym name
  • acrosin-trypsin inhibitor
  • serine protease inhibitor, Kazal type, 2 (acrosin-trypsin inhibitor)
  • Synonym symbol(s) HUSI-II
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D4S1619 - SPINK2 - D4S1600 - D4S2987 - D4S416 - D4S409 - D4S392 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 591 9 84 - Wapenaar (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inhibitor from seminal plasma that may therefore be seen as the natural antagonist of the sperm protease acrosin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for celiac disease susceptibility
    Marker
    Therapy target
    ANIMAL & CELL MODELS