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FLASH GENE
Symbol SPINDOC contributors: mct - updated : 09-03-2018
HGNC name spindlin interactor and repressor of chromatin binding
HGNC id 25115
Location 11q13.1      Physical location : -
Synonym name
  • uncharacterized protein C11orf84
  • SPIN1 docking protein
  • Synonym symbol(s) C11orf84, SPIN-DOC
    DNA
    TYPE functioning gene
    STRUCTURE 14.34 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2055 - 381 - 2017 29061846
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • SPINDOC associates with TCF4 in a SPIN1-dependent manner and dampens SPIN1 coactivator activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPINDOC directly binds SPIN1 and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin
  • SPIN2A, 2B, 3, and 4, also bind SPINDOC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS