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FLASH GENE
Symbol SPIN1 contributors: mct/npt - updated : 08-03-2018
HGNC name spindlin 1
HGNC id 11243
Location 9q22.1      Physical location : 91.003.296 - 91.093.620
Synonym name
  • ovarian cancer-related protein
  • spindlin
  • Synonym symbol(s) OCR, SPIN, TDRD24
    DNA
    TYPE functioning gene
    STRUCTURE 90.33 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text abundant maternal transcript in mouse
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 4535 29 262 - 2014 24589551
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Cardiovascularheart   highly
    Digestiveliver    
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines ovarian carcinoma
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text early, infertilized egg, associating with the meiotic cycle and phosphorylated in a cell dependent cycle fashion
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three repeats of five/four anti-parallel beta-strands, exhibiting a novel arrangement of tandem Tudor-like domains
  • C-terminal correlated with nuclear localization of Spindlin 1 protein
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Spin
    homolog to C.elegans K05G3.1
    Homologene
    FAMILY
  • SPIN/STSY family
  • Spindlin family of coactivators
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    intracellular,nuclear envelope
    text
  • localized to interphase nucleus and mitotic chromosomes
  • in interphase cells, SPIN1 specifically localizes to the nucleoli, and localizes to the active ribosomal DNA (rDNA) repeats, facilitating the expression of rRNA genes 6)
  • basic FUNCTION
  • playing a role in cell-cycle regulation during the transition from gamete to embryo
  • important gene for mitotic chromosome functions, and its disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis
  • meiotic spindle-binding protein, involved in gametogenesis
  • target for cell cycle-dependent phosphorylation and disturb the cell cycle
  • is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis
  • meiotic spindle-associated protein
  • is a histone methylation effector protein that specifically recognizes H3K4 methylation
  • involved in the process of spindle organization and chromosomal stability and plays a role in the development of cancer
  • regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
  • histone effector that senses a cis-tail histone H3 methylation pattern involving trimethyllysine 4 (H3K4me3) and asymmetric dimethylarginine 8 (H3R8me2a) marks
  • is a transcriptional coactivator with critical functions in embryonic development and emerging roles in cancer
  • regulates gene expression in the Wnt signaling pathway by directly interacting with transcription factor 4 (TCF4)
  • histone code reader SPIN1 controls skeletal muscle development
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS development
    text
  • early embryogenesis
  • cell-cycle regulation
  • PATHWAY
    metabolism
    signaling
    a component
  • SPIN1, via its Tudor-like domain, forms a ribonucleoprotein complex with SERBP1, and regulating mRNA stability and/or translation
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • associations with nucleic acid to provide a biochemical basis for its cell cycle regulation and other functions
  • AURKA could interact with and phosphorylate SPIN1 at its key functional sites, Ser84 and Ser99, suggesting that phosphorylation of SPIN1 is involved in its oncogenic function
  • SPIN1, a maternal protein containing Tudor-like domains, interacts with a known mRNA-binding protein SERBP1, and is involved in regulating maternal transcripts to control meiotic resumption
  • SPIN1 directly enhances expression of GDNF, an activator of the RET signaling pathway, in cooperation with the transcription factor MAZ
  • SPINDOC directly binds SPIN1 and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin
  • SPINDOC is a transcriptional repressor that binds SPIN1 and masks its ability to engage the H3-Lys-4 trimethylation activation mark
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer
    constitutional     --over  
    disrupting mitotic segregation and resulting in multinucleation, cell senescence and apoptosis
    tumoral     --over  
    in drug-resistant and metastatic breast cancer tissues (pMID: 27171498)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    targeting SPIN1 chromatin association with small molecule inhibitors may represent a novel therapeutic strategy in liposarcoma
    ANIMAL & CELL MODELS