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FLASH GENE
Symbol SPHK2 contributors: mct - updated : 23-08-2007
HGNC name sphingosine kinase 2
HGNC id 18859
Location 19q13.2      Physical location : 49.122.547 - 49.133.661
EC.number 2.7.1.-
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CARD8 19q13.33 caspase recruitment domain family, member 8 MGC17986 19q13.33 hypothetical protein MGC17986 FLJ32926 19q13.33 hypothetical protein FLJ32926 EMP3 19q13.3 epithelial membrane protein 3 FLJ10922 19q13.33 hypothetical protein FLJ10922 SYNGR4 19q13.3 synaptogyrin 4 KDELR1 19q13.2-q13.3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 GRIN2D 19q13.1-qter glutamate receptor, ionotropic, N-methyl D-aspartate 2D GRWD1 19q13.33 glutamate-rich WD repeat containing 1 KCNJ14 19q13 potassium inwardly-rectifying channel, subfamily J, member 14 PSCD2 19q13.3 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) KIAA1883 SULT2B1 19q13.3 sulfotransferase family, cytosolic, 2B, member 1 FLJ20200 19q13.33 hypothetical protein FLJ20200 SPACA4 19q13.3-14 sperm acrosome associated 4 RPL18 19q13.3 ribosomal protein L18 SPHK2 19q13.2 sphingosine kinase 2 DBP 19q13.3 D site of albumin promoter (albumin D-box) binding protein CA11 19q13.3 carbonic anhydrase XI LOC126147 19q13.33 hypothetical protein BC018697 FUT2 19q13.3 fucosyltransferase 2 (secretor status included) FLJ36070 19q13.33 hypothetical protein FLJ36070 RAIN 19q13.33 Ras-interacting protein MGC34799 19q13.33 hypothetical protein MGC34799 FUT1 19q13.3 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included) FGF21 19q13.1-qter fibroblast growth factor 21 BCAT2 19q13.3 branched chain aminotransferase 2, mitochondrial DHRS10 19q13.33 dehydrogenase/reductase (SDR family) member 10 PLEKHA4 19q13.33 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 PPP1R15A 19q13.2 protein phosphatase 1, regulatory (inhibitor) subunit 15A TULP2 19q13.1 tubby like protein 2 NUCB1 19q13.32 nucleobindin 1 DHDH 19q13.3 dihydrodiol dehydrogenase (dimeric) BAX 19q13.3-q13.4 BCL2-associated X protein FTL 19q13.3 ferritin, light polypeptide GYS1 19q13.3 glycogen synthase 1 (muscle) RUVBL2 19q13.3 RuvB-like 2 (E. coli)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Rna function mRNA of human SPHK2 is abundant in the kidney, liver, and brain and is detected at a relatively lower level in other tissues
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouth   moderately
Lymphoid/Immunespleen   moderately
 thymus   moderately
Nervousbrain   moderately
 nervecranial nerve  highly
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tracttrachea  moderately
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
physiological period embryo
Text late embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lipid binding domain to the N-terminus (AAs 1175), a region of sequence that is absent in SPHK1, required for membrane localisation(Don 2009)
  • a diacylglycerol catalytic domain
  • HOMOLOGY
    interspecies homolog to rattus Sphk2 (84.6 pc)
    homolog to murine Sphk2 (84 pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text N-terminus is required for membrane localisation (Don 2009)
    basic FUNCTION
  • catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP
  • Also acting on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS development
    text
  • blood vessel development
  • brain development
  • positive regulation of cell proliferation
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with EEF1A1
  • cell & other
    REGULATION
    activated by phosphatidylserine
    in response to EGF, stem cell factor, interleukin-3 and IgE and is required for mast cell activation and degranulation in response to IgE (Don 2009)
    Other regulation mediated by interaction with EEF1A1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS