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FLASH GENE
Symbol SPHK2 contributors: mct - updated : 23-08-2007
HGNC name sphingosine kinase 2
HGNC id 18859
Location 19q13.2      Physical location : 49.122.547 - 49.133.661
EC.number 2.7.1.-
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Rna function mRNA of human SPHK2 is abundant in the kidney, liver, and brain and is detected at a relatively lower level in other tissues
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 mouth   moderately
Lymphoid/Immunespleen   moderately
 thymus   moderately
Nervousbrain   moderately
 nervecranial nerve  highly
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tracttrachea  moderately
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
physiological period embryo
Text late embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a lipid binding domain to the N-terminus (AAs 1175), a region of sequence that is absent in SPHK1, required for membrane localisation(Don 2009)
  • a diacylglycerol catalytic domain
  • HOMOLOGY
    interspecies homolog to rattus Sphk2 (84.6 pc)
    homolog to murine Sphk2 (84 pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text N-terminus is required for membrane localisation (Don 2009)
    basic FUNCTION
  • catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP
  • Also acting on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS development
    text
  • blood vessel development
  • brain development
  • positive regulation of cell proliferation
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with EEF1A1
  • cell & other
    REGULATION
    activated by phosphatidylserine
    in response to EGF, stem cell factor, interleukin-3 and IgE and is required for mast cell activation and degranulation in response to IgE (Don 2009)
    Other regulation mediated by interaction with EEF1A1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS