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FLASH GENE

Symbol

SPCS1

contributors: - updated : 26-04-2005

HGNC name	signal peptidase complex subunit 1 homolog (S. cerevisiae)
HGNC id	23401

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.1      Physical location : 52.739.856 - 52.742.195
Synonym name	signal peptidase 12 kDa subunit
Synonym symbol(s)	SPC1, SPC12, HSPC033
EC.number	3.4.-.-

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two transmembrane domains

HOMOLOGY

interspecies

homolog to rattus LOC290555

Homologene

FAMILY

SPC12 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION

signal peptidase activity

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

may be involved in biotin and lysine degradation

a component

component of the signal peptidase complex (composed of SPC25, SPC22/23, SPC21, SPC18 and SPCS1)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS