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FLASH GENE
Symbol SPATA6 contributors: mct - updated : 06-09-2018
HGNC name spermatogenesis associated 6
HGNC id 18309
Location 1p33      Physical location : 48.761.043 - 48.937.876
Synonym name
  • spermatogenesis-related factor-1
  • testicular tissue protein Li 178
  • Synonym symbol(s) SRF1, SRF-1, FLJ10007, HASH
    DNA
    TYPE functioning gene
    STRUCTURE 213.57 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5024 - 488 haploid cells 2015 26464655
    13 - 4976 - 472 at low levels in testis, ovary, thymus and placenta 2015 26464655
    12 - 4982 - 474 - 2015 26464655
    derived from a proximal promoter between exons 7 and 8, and contains a translation initiation codon AUG
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to C-Elegans Ncs-2
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • evolutionarily conserved testis-specific gene, encoding a protein required for formation of the segmented columns and the capitulum, two major structures of the sperm connecting piece essential for linking the developing flagellum to the head during late spermiogenesis
  • may play an important role in TGCTs (testicular germ cell tumors), and down-regulation of SPATA6 could lead to apoptosis of TGCTs
  • is a structural protein of the coupling apparatus specifically localized in the segmented columns and the capitulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is involved in myosin-based microfilament transport through interaction with myosin subunits
  • PMFBP1 cooperates with SUN5 and SPATA6 to connect sperm head to tail
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • inactivation of Spata6 in mice leads to acephalic spermatozoa and male sterility