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FLASH GENE
Symbol SPATA24 contributors: mct - updated : 08-12-2010
HGNC name spermatogenesis associated 24
HGNC id 27322
Location 5q31.2      Physical location : 138.732.457 - 138.739.776
Synonym name
  • coiled-coil domain containing 161
  • testis protein T6441 homolog
  • Synonym symbol(s) CCDC161, T6441, TIPT, TIPT2
    DNA
    TYPE functioning gene
    STRUCTURE 7.32 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 719 - 205 - 2006 16146721
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • expressed mainly in the cytoplasm of spermatids
  • in cyto- and nucleoplasma, and enriched in the nucleolus
  • with Geminin, were detected in the chromatin near TBP/TBPL1 binding sites
  • basic FUNCTION
  • may play a role in cytoplasm movement and removal during spermiogenesis
  • could contribute to the precise timing of the molecular events in male germ cells, specifically by linking transcription to chromatin remodeling in round spermatids
  • synergizes with geminin and TBP in the activation of TATA box-containing promoters, and with TBPL1 and geminin in the activation of the TATA-less NF1 promoter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBPL1 interacting protein in testis
  • interacts also with CBX5 proteins, thereby establishing an intriguing link between transcription and chromatin condensation
  • strong binding partner of Geminin (GMNN)
  • also interacts with several polycomb factors, with the general transcription factor TBP (TATA box binding protein), and with the related protein TBPL1 (TRF2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS