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FLASH GENE
Symbol SPATA13 contributors: mct/npt/pgu - updated : 10-12-2015
HGNC name spermatogenesis associated 13
HGNC id 23222
Location 13q12.12      Physical location : 24.734.860 - 24.881.212
Synonym name adenomatous polyposis coli stimulated exchange factor 2
Synonym symbol(s) FLJ31208, ASEF2, FLJ35435, MGC129988, MGC129989, RP11-307N16.3
DNA
TYPE functioning gene
STRUCTURE 143.00 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC387907 13 similar to bA271B5.1 (similar to ribosomal protein S7) FGF9 13q11-q12 fibroblast growth factor 9 (glia-activating factor) LOC387908 13 similar to Ferritin heavy chain (Ferritin H subunit) LOC390383 13 similar to inositol polyphosphate multikinase LOC387909 13 hypothetical gene supported by AK130366 LOC283530 13q12.12 hypothetical LOC283530 LOC387910 13 LOC387910 SGCG 13q12 sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) SACS 13q12 spastic ataxia of Charlevoix-Saguenay (sacsin) TNFRSF19 13q12.11-q12.3 tumor necrosis factor receptor superfamily, member 19 MIPEP 13q12 mitochondrial intermediate peptidase LOC387911 13 similar to hypothetical protein MGC48915 LOC390384 13 similar to hypothetical protein DKFZp434A171 SPATA13 13q12.13 spermatogenesis associated 13 MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin PABPC3 13q11-q12 poly(A) binding protein, cytoplasmic 3 FLJ25477 13q12.13 hypothetical protein FLJ25477 MTMR6 13q12 myotubularin related protein 6 NUPL1 13q12.12 nucleoporin like 1 LOC246717 13q12 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene ATP8A2 13q12-13 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 LOC387914 13 similar to WGAR9166 RNF6 13q12 ring finger protein (C3H2C3 type) 6 CDK8 13q12 cyclin-dependent kinase 8 WASF3 13q12 WAS protein family, member 3 LOC390389 13 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3503 74.6 652 - 2007 17599059
- - 8457 - 1277 - 2007 17599059
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   highly
Lymphoid/Immunespleen   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an APC binding region
  • a Dbl homolgy domain
  • a Src homology 3 domain
  • a Pleckstrin homology domain
  • HOMOLOGY
    interspecies homolog to murine Spata13 (87.1pc)
    homolog to rattus Spata13 (87.1pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • may be implicated in spermatogenesis
  • plays an important role in cell migration
  • regulates actin cytoskeletal organization and is required for hepatocyte growth factor-induced cell migration, in cooperation with PPP1R9B and APC
  • functions as a Cdc42 exchange factor
  • having a GEF activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with APC
  • interacts with Neurabin2/Spinophilin, a scaffold protein that binds to Filamentous actin (F-actin)
  • three regulators of the actin cytoskeleton--AMOTL2, SPATA13 and FLII--interact with PHLDB2 (pMID: 23525008
  • cell & other
    REGULATION
    activated by truncated mutant APC and is required for aberrant migration of colorectal tumor cells
    induced by APC that stimulates the GEF activity of ARHGEF4 and SPATA13 and thereby regulates cell adhesion and migration
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS