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FLASH GENE
Symbol SPARCL1 contributors: mct/npt - updated : 20-12-2016
HGNC name SPARC-like 1 (mast9, hevin)
HGNC id 11220
Location 4q22.1      Physical location : 88.394.489 - 88.450.655
Synonym name
  • hevin/MAST9
  • secreted protein acidic and rich in cysteine)-like 1
  • high endothelial venule protein
  • proliferation-inducing protein 33
  • Synonym symbol(s) SC1, PIG33, MAST9, MAST 9
    DNA
    TYPE functioning gene
    STRUCTURE 56.17 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   ALU   long interspersed repetitive elements
    MAPPING cloned Y linked N status provisional
    Map cen - D4S1534 - SPARCL1 - D4S1563 - D4S1557 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3058 - 664 - 2003 12538579
    11 - 2956 - 664 - 2003 12538579
    10 - 2670 - 539 - 2003 12538579
    12 - 3019 - 539 - 2003 12538579
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousgangliasensory gangliadorsal root   Homo sapiens
     nerve     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Nervousastrocyte Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines endothelial venule tumoral cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • glycoprotein cystein-rich
  • a highly acidic domain-I,
  • a follistatin-like domain
  • and an extracellular calcium (EC) binding domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SPARC
    Homologene
    FAMILY
  • secreted protein, acidic and rich in cysteine (SPARC) family matricellular protein
  • osteonectin family of proteins
  • CATEGORY adhesion , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte adhesion receptor for high endothelium
  • regulating the terminal phase of radial glia-guided migration in the cerebral cortex
  • having important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix (Sullivan 2006)
  • regulates dermal extracellular matrix and collagen fibril formation (Sullivan 2006)
  • having the capacity to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly (Sullivan 2006)
  • having anti-invasive effects and reduced expression in metastasis of pancreatic cancer (Esposito 2007)
  • can influence the function of astroglial cells in the developing and mature central nervous system (CNS) (Weimer 2008)
  • may be a component of the 'matrix response' involved in remodeling events associated with neuronal degeneration following neural injury (Lively 2008)
  • does not appear to be critical to regulating intraocular pressure (IOP), is expressed in trabecular meshwork (TM) but, in contrast to SPARC, does not appear to be regulated by TGFB2
  • is required for the structural maturation of the retinocollicular synapses
  • SPARCL1 is a positive and SPARC is a negative regulator of synapse formation
  • possible role for this protein in the progression of the glioma
  • is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence
  • is a matricellular protein involved in tissue repair and remodeling via interaction with the surrounding extracellular matrix (ECM) proteins
  • plays a pivotal role in the corneal wound healing
  • SPARCL1-containing neurons function to relay and regulate motor and sensory signals in the human brainstem
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in clear cell renal carcinoma with good outcome
    tumoral     --low  
    may be related to inactivation of its tumor suppressor functions and might play an important role in the development of gastric adenocarcinoma
    tumoral     --over  
    in primary colorectal adenocarcinomas and slightly expressed in their lymph node metastases
    Susceptibility to multiple sclerosis (minor role) (Scalabrini 2007)
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis
  • Therapy target
    ANIMAL & CELL MODELS
  • Blbf-Sparcl1 transgenic mice show elevated Sparcl1 transcript and protein in an astroglial selective pattern throughout the CNS (Weimer 2008)
  • Hevin-null mice had fewer excitatory synapses
  • Hevin (-/-) mice develop early corneal haze characterized by severe chronic inflammation and stromal fibrosis that can be rescued with exogenous administration of rhHevin