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FLASH GENE
Symbol SPANXA1 contributors: mct - updated : 25-08-2007
HGNC name sperm protein associated with the nucleus, X chromosome, family member A1
HGNC id 11218
Location Xq27.1      Physical location : 140.671.806 - 140.678.888
Synonym name
  • SPANX family, member A1
  • nuclear-associated protein SPAN-Xa
  • Synonym symbol(s) SPANX, SPAN-XA, SPAN-XB, SPANX, SPANX-A2, SPANX-C, SPANX-D, SPANXA2, SPANXC, SPANXD
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text
  • five SPANX genes (SPANX-A1, -A2, -B, -C, and -D) encoding sperm proteins associated with the nucleus
  • SPANX genes are >95p100 identical and reside within large segmental duplications (SDs) with a high level of similarity
  • STRUCTURE 1.00 kb     2 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure association of MECP2 with the promoter (MECP2 binding strongly correlated with repression of SPANXA1) in myeloma cells
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Reproductivespermatid
    cell lineage
    cell lines in melanoma and glioblastoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY SPANX family of cancer/testis-associated genes
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope
    text associated with nuclear envelope of human spermatids and spermatozoa
    basic FUNCTION
  • cancer-testis antigen in multiple myeloma
  • provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target useful target in cancer immunotherapy
    ANIMAL & CELL MODELS