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FLASH GENE
Symbol SPAM1 contributors: mct - updated : 16-09-2014
HGNC name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
HGNC id 11217
Location 7q31.32      Physical location : 123.565.285 - 123.611.459
Synonym symbol(s) PH20, HYAL3, SPAG15, HYA1, HYAL1, HYAL5, PH-20
EC.number 3.2.1.35
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with HYAL4 and HYALP1
STRUCTURE 46.18 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • in the proximal promoter of SPAM1 were uncovered putative epididymal transcription factor binding sites including androgen receptor elements (AREs), consistent with epididymal expression
  • MAPPING cloned Y linked N status confirmed
    Physical map
    TM4SF12 7 transmembrane 4 superfamily member 12 ING3 7q31 inhibitor of growth family, member 3 FLJ21986 7q31.32 hypothetical protein FLJ21986 WNT16 7q31 wingless-type MMTV integration site family, member 16 FAM3C 7q22.1-q31.1 family with sequence similarity 3, member C HCP19 7q31.32 cytochrome c, somatic pseudogene LOC136143 7q31.32 similar to ribosomal protein L18; 60S ribosomal protein L18 PTPRZ1 7q31.3 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 AASS 7q31.3 aminoadipate-semialdehyde synthase LOC389549 7 similar to zinc finger protein 312; forebrain embryonic zinc finger CADPS2 7q31.1 Ca2+-dependent activator protein for secretion 2 RNF133 7q31.33 ring finger protein 133 RNF148 7q31.33 ring finger protein 148 TAS2R16 7q31.1-q31.3 taste receptor, type 2, member 16 SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 FLJ35834 7q31.33 hypothetical protein FLJ35834 NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 LOC389550 7 similar to cardiac leiomodin WASL 7q31.3 Wiskott-Aldrich syndrome-like HYAL4 7q31.3 hyaluronoglucosaminidase 4 SPAM1 7q31.3 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) LOC340344 7q31.33 similar to RIKEN cDNA 6332401O19 gene LOC136157 7q31.33 similar to RIKEN cDNA 1500011L16 LOC346643 7q31.33 similar to 40S ribosomal protein S2 GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC154872 7q31.33 hypothetical LOC154872 POT1 7q31.33 protection of telomeres 1 LOC392094 7 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (PRO1608) GRM8 7q31.3-q32.1 glutamate receptor, metabotropic 8 LOC346646 7q32.2 similar to Protein C20orf45 (CGI-107) LOC168850 7q32.2 hypothetical protein LOC168850
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2438 - 511 - 1995 8575780
    5 - 2241 - 509 - 1995 8575780
    5 - 2052 - 509 - 1995 8575780
    6 - 2235 - 509 - 1995 8575780
    5 - 2151 - 509 - 1995 8575780
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
     male systemmale genital tractepididymis   Homo sapiens
     male systemmale genital tractvas deferens   Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Spam
    homolog to C.elegans y51a2d.13
    Homologene
    FAMILY family 56 of glycosyl hydrolases
    CATEGORY adhesion , enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • sperm adhesion molecule possessing hyaluronidase activity
  • involved in sperm-egg interaction
  • is likely to play an important function, possibly in sperm maturation
  • is implicated in fluid reabsorption and urine concentration
  • may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLU facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and sperm membranes
  • interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction, coupled with the complete failure of this process when HSPA2 is depleted in infertile patients
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in demyelinating lesions and increased SPAM1 expression is sufficient to inhibit Oligodendrocyte progenitor cells (OPCs) maturation and remyelination
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    . Pharmacological inhibition of PH20 may therefore be an effective way to promote remyelination in multiple sclerosis and related conditions
    ANIMAL & CELL MODELS