Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SPAG4

contributors: - updated : 20-11-2006

HGNC name	sperm associated antigen 4
HGNC id	11214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q11.21      Physical location : 34.203.808 - 34.208.965
Synonym name	sperm tail protein
	acrosomal protein ACR55
	outer dense fiber-associated protein SPAG4

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       moderately Endocrine pancreas       moderately Hearing/Equilibrium ear inner cochlea   highly Reproductive male system testis     specific Respiratory lung         Urinary bladder       moderately   kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage	spermatid-specific
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	basic leucine zipper (bZIP) domain
	an Unc84 (SUN) domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee SPAG4 (91.6 pc)
	homolog to rattus Spag4 (82.3 pc)

Homologene

FAMILY

CATEGORY

structural protein , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm

basic FUNCTION	involved in spermatids elongation
	May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

reproduction/sex

text	spermatogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting specifically with the 27 kDa outer dense fiber protein ODF27 in elongation spermatid
	interacting with ODF1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	potential cancer marker
Marker
Therapy target

ANIMAL & CELL MODELS