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FLASH GENE
Symbol SPAG4 contributors: - updated : 20-11-2006
HGNC name sperm associated antigen 4
HGNC id 11214
Location 20q11.21      Physical location : 34.203.808 - 34.208.965
Synonym name
  • sperm tail protein
  • acrosomal protein ACR55
  • outer dense fiber-associated protein SPAG4
  • DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   moderately
    Endocrinepancreas   moderately
    Hearing/Equilibriumearinnercochlea highly
    Reproductivemale systemtestis  specific
    Respiratorylung    
    Urinarybladder   moderately
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage spermatid-specific
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) domain
  • an Unc84 (SUN) domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee SPAG4 (91.6 pc)
    homolog to rattus Spag4 (82.3 pc)
    Homologene
    FAMILY
    CATEGORY structural protein , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm
  • basic FUNCTION
  • involved in spermatids elongation
  • May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting specifically with the 27 kDa outer dense fiber protein ODF27 in elongation spermatid
  • interacting with ODF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential cancer marker
    Marker
    Therapy target
    ANIMAL & CELL MODELS