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FLASH GENE
Symbol SPAG17 contributors: mct - updated : 28-09-2021
HGNC name sperm associated antigen 17
HGNC id 26620
Corresponding disease
SPGF55 spermatogenic failure 55
Location 1p12      Physical location : 118.496.287 - 118.727.848
Synonym name projection protein PF6
Synonym symbol(s) PF6, FLJ34497, RP4-776P7.2, FLJ44343, FLJ44353, DKFZp434B0610, FLJ34497, FLJ44343, CT143
DNA
TYPE functioning gene
STRUCTURE 231.64 kb     49 Exon(s)
regulatory sequence Promoter
Binding site
text structure absence of a TATA box, and putative binding sites for several factors implicated in spermatogenesis (CREB/CREM, SOX17 and SPZ1) as well as ciliogenesis (FOXJ1
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
49 - 7203 - 2223 - 2005 15827353
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemuterus  moderately
 male systemtestis  predominantly Homo sapiens
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
intracellular,nucleus
text
  • localized to the central apparatus of the sperm flagellar axoneme
  • present in the axoneme central pair complex of motile cilia and flagella
  • basic FUNCTION
  • plays a critical role in the function and structure of motile cilia, and that neonatal lethality is likely explained by impaired airway mucociliary clearance
  • potential functions for SPAG17 in the regulation of skeletal growth and mineralization, perhaps because of its role in primary cilia of chondrocytes and osteoblasts
  • is essential for normal manchette structure, protein transport, and formation of the sperm head and flagellum, in addition to its role in sperm motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SPAG17, SPAG6, and SPAG16 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat
    INTERACTION
    DNA
    RNA
    small molecule
    protein associates with SPAG6
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF55
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Spag17 knockout mice are infertile because of a severe defect in spermatogenesis