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FLASH GENE
Symbol SPAG16 contributors: mct/npt - updated : 01-02-2010
HGNC name sperm associated antigen 16
HGNC id 23225
Location 2q34      Physical location : 214.149.115 - 215.275.224
Synonym name
  • sperm-associated WD repeat protein
  • WD repeat domain 29
  • Pf20 protein homolog
  • Synonym symbol(s) FLJ22724, FLJ37717, MGC87036, PF20, WDR29, DKFZp666P1710
    DNA
    TYPE functioning gene
    STRUCTURE 1126.11 kb     16 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure absence of a TATA box, and putative binding sites for several factors implicated in spermatogenesis (CREB/CREM, SOX17 and SPZ1) as well as ciliogenesis (FOXJ1)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2189 71 631 - Zhang (2007)
  • SPAG16L
  • meiotically expressed 71-kDa protein is incorporated into the central apparatus (Zhang 2004)
  • essential for sperm flagellar function (Zhang 2006)
  • 5 - 1296 35 183 nuclear, testis-specific Zhang (2007), Zhang (2009)
  • represents the C-terminus (exons 11-16) of SPAG16L
  • SPAG16S
  • bind to meiosis expressed gene 1 product (MEIG1), a protein originally thought to play a role in meiosis
  • 35-kDa protein, which accumulates in postmeiotic male germ cells, is abundant in the nucleus
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervousbrain    
     nervespinal nervesciatic highly
    Reproductivefemale systemovary   
     male systemtestis  highly
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Respiratoryalveolar cell type II
    Respiratoryepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal WD repeats
  • HOMOLOGY
    interspecies ortholog to Chlamydomonas Pf20
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text localized to the tails of permeabilized sperm, in the axoneme central apparatus
    basic FUNCTION
  • bi-functional gene essential for spermatogenesis (Zhang 2009)
  • essential component of the axoneme central apparatus, that has multiple functions during spermatogenesis (Zhang 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS