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FLASH GENE
Symbol SPAG11B contributors: mct - updated : 08-02-2008
HGNC name sperm associated antigen 11B
HGNC id 14534
Location 8p23.2      Physical location : 7.305.275 - 7.707.685
Synonym name
  • HE2 alpha1
  • epididymis-specific protein
  • Synonym symbol(s) HE2, EP2, EP2C, EP2D, SPAG11, MGC61846
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 15.00 kb     4 Exon(s)
    regulatory sequence Promoter
    text structure with beta defensin DEFB1
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text at least nine transcripts differing in their N and C termini
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 794 11.3 103 - Hamil, Avellar (2004)
    - splicing 718 14.5 133 - Hamil, Avellar (2004)
    4 splicing 755 11.8 108 - Hamil, Avellar (2004)
    3 splicing 677 9 82 - Hamil, Avellar (2004)
    - splicing 530 8.1 74 - Hamil
    - - 530 - 113 - Avellar (2004)
    - - 520 - 50 - Avellar (2004)
    - - 444 - 80 - Avellar (2004)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
     brainhindbrainmedulla oblongata  
    reproductiveepididymis    
    Reproductivemale systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to beta defensin
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text small secretory protein
    basic FUNCTION may be involved in sperm maturation
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • sperm maturation,storage,protection
  • antimicrobial
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    higher genomic copy number associated with risk of psoriasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS