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FLASH GENE
Symbol SPACA1 contributors: np/ - updated : 09-06-2005
HGNC name sperm acrosome associated 1
HGNC id 14967
Location 6q15      Physical location : 88.757.506 - 88.776.549
Synonym name
  • sperm acrosome membrane protein 32
  • sperm acrosome membrane-associated protein 1
  • Synonym symbol(s) SAMP32, MGC32952
    DNA
    TYPE functioning gene
    STRUCTURE 19.04 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1501 - 294 - 2002 11870081
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa
    cell lineage spermatids
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a potential transmembrane domain in the C-terminus
  • an N-terminal domain homologous to the major malarial circumsporozoite surface protein
  • a domain similar to that of Krp1 from Schizosaccharomyces pombe in its carboxyl terminus
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast S.pombe Krp1
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text acrosomal membrane of spermatids and mature spermatozoa
    basic FUNCTION
  • playing a role in acrosomal morphogenesis and in sperm-egg binding and fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding to egg (oocyte)
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS