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FLASH GENE
Symbol SPA17 contributors: - updated : 17-09-2005
HGNC name sperm autoantigenic protein 17
HGNC id 11210
Location 11q24.2      Physical location : 124.543.739 - 124.564.685
Synonym name
  • sperm protein 17
  • sperm surface protein
  • Synonym symbol(s) SP17-1, SP17
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivefemale systemovary   
     male systemtestis   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa
    cell lineage
    cell lines testis cancer cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one Iq domain
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Spa17
    Homologene
    FAMILY cancer-testis antigen family
    CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • important role in cell migration and/or adhesion in somatic cells as well as in male germ cells
  • involved in the interaction of the spermatozoa with the zona pellucida of the oocyte surrounding extracellular glycoprotein matrix
  • cancer-testis antigen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS