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FLASH GENE
Symbol SP8 contributors: np - updated : 09-06-2005
HGNC name Sp8 transcription factor
HGNC id 19196
Location 7p21.1      Physical location : 20.821.894 - 20.826.508
Synonym name
  • specificity protein 8
  • nuttonhead, Drosophila, homolog of
  • Synonym symbol(s) BTD
    DNA
    TYPE functioning gene
    STRUCTURE 4.62 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 3642 - 508 - Milona (2004)
    3 splicing 3738 - 490 - Milona (2004)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • three C2H2-type zinc fingers
  • HOMOLOGY
    interspecies homolog to Drosophila btd
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating mRNA synthesis from genes that contain functional recognition sites
  • is required during corticogenesis to sustain a normal progenitor pool, and to control preplate splitting, as well as the specification of cellular diversity (Zembrzycki 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds to GC box promoters elements
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS