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FLASH GENE

Symbol

SP8

contributors: np - updated : 09-06-2005

HGNC name	Sp8 transcription factor
HGNC id	19196

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p21.1      Physical location : 20.821.894 - 20.826.508
Synonym name	specificity protein 8
	nuttonhead, Drosophila, homolog of
Synonym symbol(s)	BTD

DNA

TYPE	functioning gene
STRUCTURE	4.62 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_182700 2 splicing 3642 NP_874359 - 508 - Milona (2004) NM_198956 3 splicing 3738 NP_945194 - 490 - Milona (2004)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
	three C2H2-type zinc fingers

HOMOLOGY

interspecies

homolog to Drosophila btd

Homologene

FAMILY

Sp1 C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	activating mRNA synthesis from genes that contain functional recognition sites
	is required during corticogenesis to sustain a normal progenitor pool, and to control preplate splitting, as well as the specification of cellular diversity (Zembrzycki 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	binds to GC box promoters elements

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS