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FLASH GENE

Symbol

SP110

contributors: mct - updated : 14-09-2011

HGNC name	SP110 nuclear body protein
HGNC id	5401

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	VODI hepatic venoocclusive disease with immunodeficiency
Location	2q37.1      Physical location : 231.033.644 - 231.090.444
Synonym name	interferon-induced protein 41, 30kD
	speckled 110 kDa
	transcriptional coactivator Sp110
	phosphoprotein 75
	phosphoprotein 41
Synonym symbol(s)	IFI41, IFI75, FLJ22835, IPR1

DNA

TYPE	functioning gene
STRUCTURE	56.81 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004509 15 - 2519 NP_004500 78 689 - 2004 15308735 NM_004510 15 - 2099 NP_004501 - 549 - 2004 15308735 binds RARA and acting as a transcriptional corepressor NM_080424 19 - 2591 NP_536349 - 713 - 2004 15308735 NM_001185015 16 - 2137 NP_001171944 - 555 - 2000 10913195

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   tonsils       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two chromo domains
	an helicase ATP-binding domain
	an helicase C-terminal domain
	two PHD-type zinc fingers

HOMOLOGY

interspecies

ortholog to murine Ipr1

Homologene

FAMILY

SP100/SP140 family of nuclear body proteins

CATEGORY

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	leukocyte-specific nuclear body component, functioning as an activator of gene transcription and may be as a nuclear hormone receptor coactivator
	may also function in polycomb group (PCG) repression of HOX genes
	functions as a nuclear hormone receptor transcriptional coactivator and plays an important role in immunoprotective mechanisms against pathogens in humans
	plays an important role in resisting intracellular pathogens

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	member of the nuclear body (NB) components

INTERACTION

DNA

RNA

small molecule

protein	associated with the PML nuclear body
	RSF1 and ATF7IP are very likely interacting with SP110 during the process of viral infections

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

VODI

Susceptibility

to pulmonary tuberculosis (minor role)

Variant & Polymorphism SNP	increasing the risk of pulmonary tuberculosis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     important drug target for preventing intracellular pathogen diseases, intracellular cancers digestive liver   important drug target for preventing intracellular pathogen diseases, such hepatic veno-occlusive disease immunology infectious   important drug target for preventing intracellular pathogen diseases, such as tuberculosis

ANIMAL & CELL MODELS