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FLASH GENE
Symbol SP100 contributors: mct - updated : 12-06-2013
HGNC name nuclear antigen SP100
HGNC id 11206
Location 2q37.1      Physical location : 231.280.870 - 231.410.317
Synonym name speckled, 100kD
Synonym symbol(s) LEU5, RFP2, LYSP100B
DNA
TYPE functioning gene
STRUCTURE 129.45 kb     25 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ20701 2q37.1 hypothetical protein FLJ20701 DNER 2q37.1 delta-notch-like EGF repeat-containing transmembrane TRIP12 2q36.1 thyroid hormone receptor interactor 12 LOC130888 FLJ30794 SP110 2q37.1 SP110 nuclear body protein SP140 2q36.1 SP140 nuclear body protein LOC93349 2q37.1 hypothetical protein BC004921 SP100 2q37.1 nuclear antigen SP100 HMG1L3 2q35 high-mobility group (nonhistone chromosomal) protein 1-like 3 LOC389079 2 similar to tropomyosin 3 LOC391489 2 similar to LOC93349 protein MO25 2q37.1 MO25 protein ITM2C 2q37 integral membrane protein 2C GPR55 2q37 G protein-coupled receptor 55 TSARG1 LOC389080 2 LOC389080 PSMD1 2q37.1-q37.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 HTR2B 2q36.3-q37.1 5-hydroxytryptamine (serotonin) receptor 2B FLJ12584 2q37.1 hypothetical protein FLJ12584 FLJ23510 2q37.1 hypothetical protein FLJ23510 LOC389081 2 LOC389081 B3GNT7 2q36.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 LOC389082 2 similar to archease NCL 2q12-qter nucleolin MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174
RNA
TRANSCRIPTS type messenger
text three variants SP100, SP100B, SP100.HMG.1 (chimeric fusion between SP100 and a HMG1-like peptide)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 5455 - 885 - 2011 22086178
  • SP100C
  • 25 - 3688 - 879 - 2011 22086178
  • SP100-HMG
  • 24 - 2313 - 688 - 2011 22086178
  • SP100B
  • 15 - 2015 - 480 - 2011 22086178
  • SP100A
  • one of the major components of PML nuclear bodies (NBs) that exhibit intrinsic antiviral activity against several viruses
  • 14 - 1931 - 452 - 2011 22086178
    - - 2050 - 445 - 201 22086178
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAND (SP100, AIRE, NUCP41/75, DEAF1 suppression) DNA binding domain
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,nucleolus
    text
  • constituent of the nuclear body
  • localizes to nuclear particles during interphase and disperses from them during mitosis
  • basic FUNCTION
  • regulator of transcriptional activity
  • negatively modulates ETS1-dependent downstream biological processes )
  • role as a tumor suppressor in addition to its role in maintaining ND10/PML bodies and in the epigenetic regulation of gene expression
  • may play an additional antiviral role during the late phase
  • is the first ND10-related factor identified that not only possesses the potential to restrict the initial stage of infection but also inhibits HCMV replication during the late phase
  • interferon-inducible SP100 proteins are thought to play roles in the chromatin pathway and in transcriptional regulation
  • participates in viral resistance, transcriptional regulation, and apoptosis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the nuclear body
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to members of heterochromatin protein (HP1) families of non histone chromosomal proteins
  • enhancing ETS1 transcriptional activity
  • interacts with the ETS1 transcription factor, reduces ETS1-DNA binding and inhibits ETS1 transcriptional activity on the MMP1 and PLAU promoters
  • CDC20 is involved the degradation of SP100 and this process requires the D-box module
  • cell & other
  • major mediator of EBNA-LP coactivation
  • REGULATION
    Other degraded in a proteasome-dependent manner at late times postinfection, suggesting that SP100 may play an additional antiviral role during the late phase
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in the late stages of HCMV infection
    Susceptibility
    Variant & Polymorphism other
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS