basic FUNCTION
| transcriptional activator in embryonic heart developing CNS, lung, tooth-bud, mesonephros, genitalia, pre B and T cells |
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modulator of LINE retroposons promoter activity |
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central regulatory role during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties |
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has a role in insulin secretion in the adult beta-cell downstream of the K(ATP) channel |
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DNA damage sensor, required for the activation of TP53 tumor suppressor in response to DNA damage |
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promotes cell cycle arrest and apoptosis, and inhibits tumorigenesis in a TP53-dependent manner |
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transcription factor involved in embryonic cell differentiation |
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recently implicated in pancreas development and the regulation of insulin secretion |
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is a mediator of TBX3 transcriptional activity |
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SOX4 and CREB1 cooperate and contribute to increased proliferation of hematopoietic progenitor cells |
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SOX11 and SOX4 play critical roles in retinal development, during which they display specific and unique expression patterns |
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SOX4 is a master regulator of EMT by governing the expression of the epigenetic modifier EZH2 |
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is required to limit the extent of Hh signaling during eye development |
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contributes to the regulation of Schwann cell myelination, indicating its involvement in the pathophysiology of peripheral neuropathies |
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SOX4-centered physical network during myoblast differentiation |
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is a new regulator of cholangiocyte development |
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SOX4 and SOX9 control formation of primary cilia, which are known signaling regulators |
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is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9 |
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implicated in skeletal myoblast differentiation through the regulation of CALD1 gene expression |
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is a critical component of the PTEN/PI3K/AKT1 pathway in prostate cancer |
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play key roles, often in redundancy, in multiple developmental pathways, including neurogenesis and skeletogenesis |
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is a critical gene for human global, intellectual, and skeletal development |
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significantly participate in neurogenesis and other aspects of embryonic development |