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FLASH GENE
Symbol SOX21 contributors: npt/ - updated : 19-01-2008
HGNC name SRY (sex determining region Y)-box 21
HGNC id 11197
Location 13q31-q32      Physical location : 95.361.881 - 95.364.389
Synonym name
  • SRY-box 21
  • transcription factor SOX-21
  • Synonym symbol(s) SOX25, SOXA
    DNA
    TYPE functioning gene
    STRUCTURE 2.51 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GPC6 13q32 glypican 6 DCT 13q32 dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) TGDS 13q32.1 TDP-glucose 4,6-dehydratase ITR 13q32.1 intimal thickness-related receptor SOX21 13q31-q32 SRY (sex determining region Y)-box 21 LOC387941 13 LOC387941 LOC341583 13q32.1 similar to bromodomain containing 7; bromodomain protein; bromodomain-containing 7 LOC387942 13 LOC387942 ABCC4 13q31 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 CLDN10 13q31-q34 claudin 10 DZIP1 13q32.1 claudin 10 DNAJC3 13q32 DnaJ (Hsp40) homolog, subfamily C, member 3 UGCGL2 13q32.1 UDP-glucose ceramide glucosyltransferase-like 2 HS6ST3 13 heparan sulfate 6-O-sulfotransferase 3 LOC283476 13q32.2 hypothetical protein LOC283476 LOC390420 13 similar to heat shock protein 84 - mouse LOC341592 13q32.2 similar to tubby like protein 3 GPR80 13q32.2 G protein-coupled receptor 80 MBNL2 13q31.1 muscleblind-like 2 (Drosophila) RAP2A 13q34 RAP2A, member of RAS oncogene family LOC121906 13q32.2 similar to Proteasome subunit alpha type 6 (Proteasome iota chain) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (27 kDa prosomal protein) (PROS-27) (p27K)
    regionally located between markers D13S167 and D13S154
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 800 28.6 276 - Malas
    - - - 5000 - - embryonic brain Malas
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA binding protein with an high mobility group (HMG) domain
  • a transactivation domain in the carboxyl terminus (transcription activation),B subfamily
  • three polyalanine tracts
  • HOMOLOGY
    interspecies homolog to C.elegans f40e10.2
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factors
  • subgroup B
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • involved in embryonic CNS development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text negative regulator of transcription
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS