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FLASH GENE
Symbol SOX14 contributors: - updated : 26-05-2006
HGNC name SRY (sex determining region Y)-box 14
HGNC id 11193
Location 3q22-q23      Physical location : 137.483.578 - 137.484.396
Synonym name HMG box transcription factor SOX-14
Synonym symbol(s) MGC119899, SOX28, SRY-box 14
DNA
TYPE functioning gene
STRUCTURE 0.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
text structure CCAAT box motif present in the promoter plays a functional role in the transcription of this gene
MAPPING cloned Y linked N status confirmed
Map pter - D3S1267 - D3S1589 - D3S1292 - D3S3641 /D3S3696 - D3S1590 - D3S1615 - D3S2453 - D3S3528 - D3S1549 - D3S3349 - D3S1576 - SOX14 - D3S3586 - RBP2 - RBP1 - D3S3554 - D3S2983 - D3S1316 - D3S1744 - cen
Authors de Baere (99), Hargrave (00), LDB (99)
Physical map
LOC391580 3 similar to Succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (Ip) (Iron-sulfur subunit of complex II) PPP2R3A 3q22.2-q protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha FLJ10546 3q22.2 hypothetical protein FLJ10546 LOC391581 3 similar to ribosomal protein L31 PCCB 3q21-q22 propionyl Coenzyme A carboxylase, beta polypeptide STAG1 3q22-q24 stromal antigen 1 MGC3295 3q22.3 hypothetical protein MGC3295 NCK1 3q21 NCK adaptor protein 1 MGC34923 3q22.3 hypothetical protein MGC34923 NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   predominantly
Nervousspinal cord   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text predominantly in fetal brain,apical ectodermal ridge
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain
  • a bipartite localization signal (NLS) on the N terminal domain of the HMG box
  • a transactivation domain in the carboxyl terminus (transcription activation)
  • HOMOLOGY
    interspecies homolog to murine Sox14
    homolog to C.elegans f40e10.2
    Homologene
    FAMILY class B SRY-related HMG BOX family of transcription factor
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as a negative regulator of transcription
  • modulator of LINE retroposons promoter activity
  • potentially involved in regulation of nervous system development and in limb development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS