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FLASH GENE
Symbol SOX12 contributors: mct - updated : 22-12-2015
HGNC name SRY (sex determining region Y)-box 12
HGNC id 11198
Location 20p13      Physical location : 306.238 - 310.865
Synonym name SRY (sex determining region Y)-box 22
Synonym symbol(s) SOX22
DNA
TYPE functioning gene
STRUCTURE 4.66 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • forkhead box Q1 (FOXQ1) directly bound to the SOX12 promoter and transactivated its expression, which contributed to SOX12 overexpression in human hepatocellular carcinoma
  • MAPPING cloned Y linked   status provisional
    Physical map
    DEFB125 20p13 defensin, beta 125 DEFB126 20p13 defensin, beta 126 DEFB127 20p13 defensin, beta 127 DEFB129 20p13 defensin, beta 129 C20orf96 20p13 chromosome 20 open reading frame 96 C20orf99 20p13-p12.2 chromosome 20 open reading frame 99 SOX12 20p13 SRY (sex determining region Y)-box 12 C20orf98 20p13 chromosome 20 open reading frame 98 C20orf97 20p12.2-p13 chromosome 20 open reading frame 97 C20orf18 20p13 chromosome 20 open reading frame 18 C20orf140 20p13 chromosome 20 open reading frame 140 CSNK2A1 20p13 casein kinase 2, alpha 1 polypeptide TCF15 20p13 transcription factor 15 (basic helix-loop-helix) C20orf139 20p13 chromosome 20 open reading frame 139 LOC391226 20 similar to dJ850E9.1 (novel C2H2 type zinc finger protein similar to Drosophila Scratch (Scrt), Slug and Xenopus Snail) C20orf54 20p13 chromosome 20 open reading frame 54 RPS10L 20p13 ribosomal protein S10-like C20orf55 20p13 chromosome 20 open reading frame 55 ANGPT4 20p13 angiopoietin 4 LOC343637 20p13 similar to dJ824F16.3 (novel protein similar to mouse thrombospondin type 1 domain protein R-spondin) PSMF1 20p13-p12.2 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4658 34 315 - 2008 18505825
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Reproductivefemale systemovary  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain and kidney highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • DNA binding protein with an high mobility group (HMG) domain, C subfamily
  • a transactivation domain in the carboxyl terminus (transcription activation)
  • HOMOLOGY
    interspecies homolog to C.elegans t06e.11
    Homologene
    FAMILY
  • SRY-related HMG box family of transcription factor
  • SOXC family that includes SOX11 and SOX4
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • TMED3 and SOX12 belong to different families involved in protein secretion and transcriptional regulation, but both promote endogenous WNT-TCF activity
  • TMED3 and SOX12 are required for efficient clonogenic behavior but only TMED3 for clone compaction
  • TMED3 and SOX12 have novel metastatic suppressive functions in human colon cancer cells
  • unlike TMED3, SOX12 is a multifunctional nuclear transcription factor that promotes CTNNB1/TCF activity
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FGFBP1 was a direct transcriptional target of SOX12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    induced by FOXQ1 promotes hepatocellular invasion and metastasis by transactivating TWIST1 and FGFBP1 expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential prognostic biomarker in hepatocellular carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    novel therapeutic target for hepatocellular carcinoma
    ANIMAL & CELL MODELS
  • Sox12-deficient mice developed surprisingly normally, so that they were born alive, showed no gross phenotypic abnormalities, and were fertile in both sexes