basic FUNCTION
| modulator of LINE retroposons promoter activity |
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TMED3 and SOX12 belong to different families involved in protein secretion and transcriptional regulation, but both promote endogenous WNT-TCF activity |
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TMED3 and SOX12 are required for efficient clonogenic behavior but only TMED3 for clone compaction |
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TMED3 and SOX12 have novel metastatic suppressive functions in human colon cancer cells |
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unlike TMED3, SOX12 is a multifunctional nuclear transcription factor that promotes CTNNB1/TCF activity |