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FLASH GENE
Symbol SOX1 contributors: - updated : 06-07-2007
HGNC name SRY (sex determining region Y)-box 1
HGNC id 11189
Location 13q34      Physical location : 112.721.912 - 112.726.020
Synonym name SRY-related HMG-box gene 1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 4.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
RAB20 13q34 RAB20, member RAS oncogene family FLJ10769 13q34 hypothetical protein FLJ10769 FLJ12118 13q34 hypothetical protein FLJ12118 ING1 13q33-q34 inhibitor of growth family, member 1 LOC387946 13 LOC387946 LOC283487 13q34 hypothetical protein LOC283487 ANKRD10 13q34 ankyrin repeat domain 10 ADPRTP1 13q34 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) pseudogene 1 LOC144962 13q34 hypothetical LOC144962 ARHGEF7 13q34 Rho guanine nucleotide exchange factor (GEF) 7 LOC121792 13q34 similar to histidine-rich protein MGC35169 13q34 hypothetical protein MGC35169 LOC387947 13 LOC387947 LOC390426 13 similar to mKIAA0324 protein SOX1 13q34 SRY (sex determining region Y)-box 1 LOC387948 13 LOC387948 LOC122258 13q34 LOC122258 TUBGCP3 13q34 tubulin, gamma complex associated protein 3 LOC387949 13 LOC387949 ATP11A 13q34 ATPase, Class VI, type 11A LOC387950 13 LOC387950 MCF2L 13q34 MCF.2 cell line derived transforming sequence-like F7 13q34 coagulation factor VII (serum prothrombin conversion accelerator) F10 13q34 coagulation factor X PROZ 13q34 protein Z, vitamin K-dependent plasma glycoprotein FLJ11305 13q34 hypothetical protein FLJ11305 CUL4A 13q34-qter cullin 4A LAMP1 13q34 lysosomal-associated membrane protein 1 GRTP1 4q14 growth hormone regulated TBC protein 1 LOC387951 13 LOC387951 ADPRHL1 13q34 ADP-ribosylhydrolase like 1 C13orf17 13q34 chromosome 13 open reading frame 17 C13orf11 13q34 chromosome 13 open reading frame 11 TFDP1 13q34 transcription factor Dp-1 ATP4B 13q34 ATPase, H+/K+ exchanging, beta polypeptide RHOK 13q34 rhodopsin kinase LOC387952 13 hypothetical gene supported by AK126042; BC034570 GAS6 13q34 growth arrest-specific 6
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text moderately in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain
  • and a transactivation domain in the carboxyl terminus (transcription activation), required for the interactions
    • HOMOLOGY
    interspecies homolog to murine Sox1
    homolog to C.elegans T28h11.1
    Homologene
    FAMILY SRY-related HMG box family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • involved in neural and lens development
  • works through multiple independent pathways to promote neuronal cell fate determination and differentiation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling
  • also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the wnt signaling pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS