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FLASH GENE
Symbol SOX1 contributors: - updated : 06-07-2007
HGNC name SRY (sex determining region Y)-box 1
HGNC id 11189
Location 13q34      Physical location : 112.721.912 - 112.726.020
Synonym name SRY-related HMG-box gene 1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 4.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text moderately in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain
  • and a transactivation domain in the carboxyl terminus (transcription activation), required for the interactions
  • HOMOLOGY
    interspecies homolog to murine Sox1
    homolog to C.elegans T28h11.1
    Homologene
    FAMILY SRY-related HMG box family of transcription factors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • involved in neural and lens development
  • works through multiple independent pathways to promote neuronal cell fate determination and differentiation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text neuronal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling
  • also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the wnt signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS