motifs/domains
| a secretory signal sequence |
|
a furin cleavage site |
|
a short cytoplasmic tail containing a tyrosine-based internalization signal and a large external part containing a VPS10 domain, which comprises a consensus sequence for cleavage by furin ((50)RRKR(53)) |
|
a LDLR-like domain with homology to the class A and class B repeats |
|
the EGF-type repeat domain of LDLR followed by six fibronectin type III modules |
|
a cluster of 11 class A repeats characteristic of the low density lipoprotein receptor gene family receptors |
|
five tandemly arranged YWTD repeats |
|
five LDL-receptor class b repeats |
|
a unique transmembrane segment and a short cytoplasmic tail |
|
six tandemly arranged fibronectin type III repeats |
| SUBCELLULAR LOCALIZATION
| extracellular
|
| plasma membrane
|
| intracellular
|
|
| intracellular,cytoplasm,organelle,membrane
|
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
|
| intracellular,cytoplasm,organelle,Golgi
|
|
| intracellular,cytoplasm,organelle,endosome
|
| basic FUNCTION
| multifonctional endocytic receptor implicated in the uptake of lipoproteins and proteases |
|
may be involved in intracellular trafficking of amyloid precursor protein  |
|
plays important roles in sporadic Alzheimer disease |
|
could play a role in cell-cell interaction |
|
acting as a sorting receptor that protects APP from processing into Abeta and thereby reduces the burden of amyloidogenic peptide formation |
|
regulator of smooth muscle cell migration |
|
having a key physiological role in the differential sorting of APP holoprotein |
|
regulator of neuronal viability and function through the regulation of both protein transport and signal transduction |
|
binds apolipoproteins and potentially modulates lipoprotein metabolism, which might also affect neuronal function. Involved in APP trafficking and metabolism. Acts as sorting receptor for APP that promotes APP |
|
transport into intracellular pathways |
|
important role in functional activation of renal ion transporters |
|
intracellular trafficking of STK39 by SORL1 is crucial for proper SLC12A1 activation and for maintenance of renal ion balance |
|
acts as an endosomal chaperone to increase APP traffic in a non-amyloidogenic pathway |
|
multifunctional low-density lipoprotein receptor that influences Alzheimer disease susceptibility |
|
SORL1, SORCS1, SORCS2, and SORCS3) play pleiotropic functions in protein trafficking and intracellular and intercellular signaling in neuronal and non-neuronal cells |
|
sortilin, SORL1, SORCS1, SORCS2, and SORCS3) modulate neurotrophic signaling pathways |
|
is a neuronal sorting receptor that is genetically associated with Alzheimer disease |
|
likely novel function for SORL1 which is in control of synapsin degradation, potentially impacting on synaptic vesicle endocytosis and/or exocytosis |
|
is an intracellular sorting receptor that directs cargo proteins, such as kinases, phosphatases, and signaling receptors, to their correct location within the cell |
|
potentially important SORL1-dependent endosomal trafficking-linked vulnerabilities in HER2-driven cancers |
|
exerts intraneuronal trafficking functions in the central nervous system 8) |
|
potential novel role of SORL1 in synaptogenesis 8) |
