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FLASH GENE
Symbol SORBS3 contributors: mct - updated : 18-12-2014
HGNC name sorbin and SH3 domain containing 3
HGNC id 30907
Location 8p21.3      Physical location : 22.409.250 - 22.433.007
Synonym name
  • vinexin beta (SH3-containing adaptor molecule-1)
  • Synonym symbol(s) SCAM-1, SCAM1, SH3D4, vinexin
    DNA
    TYPE functioning gene
    STRUCTURE 3.08 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3140 75.3 671 - 2010 20361963
    twenty exons encoding isoform 1containing a SORB domain and SH3 domains
    - - 2057 - 329 - 2010 20361963
    Sh3 domains
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
    Nervousnervecranial nerve  highly
     nerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three SH3 domains, and the third SH3 domain interacts with a proline-rich domain (PRD) located in RARG NTD
  • HOMOLOGY
    interspecies ortholog to rattus Sh3d4
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of CBL
  • may play roles in ERK-dependent cell regulation
  • adaptor protein that is implicated in cell adhesion and actin-cytoskeletal reorganization
  • regulating cytokeletal organization and signal transduction
  • regulates the proteasome-dependent degradation of WASF2 in a PKA-dependent manner
  • promotes potentially cell migration via activation of EGFR
  • crucial role of vinexin in keratinocyte migration and cutaneous wound healing
  • can help to integrate ERBB signals to promote dorsal root ganglia (DRG)neurogenesis through the activation of MAPK and upregulation of NEUROG1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the non-phosphorylated form of the AF-1 domain of RARgamma
  • substrat of MAPK1
  • binding of vinculin (vinculin-binding protein that plays a key role in cell spreading and cytoskeletal organization)
  • interacting with SAFB2
  • interacting with INPPL
  • RTKN interact with a multidomain adaptor protein, vinexin, (SORBS3) with a possible role at focal adhesion formation
  • new partner of the RARG N-Terminal domain (NTD)
  • scaffold protein known to interact with proteins involved in focal adhesions and several signaling pathways
  • genetically linked tumor suppressors SH2D4A and SORBS3 functionally cooperate to inhibit STAT3 signaling in in hepatocellular carcinoma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    with CCDC25, DLC1, PROSC, ELP3, and SH2D4A in Hepatocellular carcinoma (HCC) from patients with poor outcomes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS