basic FUNCTION
| it may be a critical regulator of early germ cell development |
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SOHLH2 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis |
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SOHLH2 might coordinate with SOHLH1 to control spermatogonial and oocyte genes, including SOHLH1, to promote the differentiation of KIT(+) germ cells |
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SOHLH1 and SOHLH2, encode basic helix-loop-helix (bHLH) transcriptional regulators that are essential in spermatogonial differentiation |
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SOHLH1 and SOHLH2 suppress genes involved in spermatogonial stem cells (SSCs) maintenance, and induce genes important for spermatogonial differentiation |
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FIGLA, LHX8, NOBOX, SOHLH1, and SOHLH2 transcriptional regulators are critical for formation and maintenance of follicles |
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SOHLH1 and SOHLH2 are essential regulators of oocyte differentiation but do not affect meiosis I |