SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,matrix
|
| intracellular,cytoplasm,organelle,membrane
|
text
| present in the mitochondrial matrix |
basic FUNCTION
| manganese superoxide dismutase catabolic pathway of activated oxygen species, free radical detoxification |
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destroying radical which are normally produced within the cells and which are toxic to biological system |
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acting as an iron toxicity modifier |
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function as the first line of antioxidant defense against highly reactive superoxide radicals |
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with MIF appear to be early predictors for survival in septic patients |
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binds with ubiquitin molecules to form polyubiquitination chains and undergoes degradation through the ubiquitin-proteasomal pathway |
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major mitochondrial antioxidative enzyme, constituting an important control switch in the process of activation-induced oxidative signal generation in T cells |
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critical role for SOD2 and mitochondria in the regulation of human T cell activation |
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regulates a "metabolic switch" during progression from quiescent through the proliferative cycle |
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is potentially a new molecular player contributing to the Warburg effect |