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FLASH GENE
Symbol SOCS7 contributors: npt/ - updated : 06-06-2007
HGNC name suppressor of cytokine signaling 7
HGNC id 29846
Location 17q12      Physical location : 36.508.004 - 36.556.017
Synonym name
  • Nck, Ash and phospholipase C binding protein
  • Nck-associated protein 4
  • Synonym symbol(s) NAP4, SOCS6, SOCS4, NCKAP4
    DNA
    TYPE functioning gene
    STRUCTURE 48.01 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2162 63 581 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal SH2 domain, was responsible for the binding to vinexin (likely one of the SH3 domains of vinexin interacts with a poly-proline region of SOCS7)
  • a central region containing several proline-rich regions
  • HOMOLOGY
    Homologene
    FAMILY
  • SOCS protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,nucleus
    basic FUNCTION
  • potent regulator of glucose homeostasis and insulin signaling
  • inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation
  • shuttling protein that transports cytoplasmic proteins into the nucleus and contributes to cell cycle arrest
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • vinexin (SORBS3) as a partner interacting with SOCS7 (interacts with vinexin and the actin cytoskeleton)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS