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FLASH GENE
Symbol SOCS5 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 5
HGNC id 16852
Location 2p21      Physical location : 46.926.098 - 46.989.926
Synonym name
  • cytokine-inducible SH2 protein 6
  • cytokine-inducible SH2-containing protein 5
  • Synonym symbol(s) CIS6, CISH6, KIAA0671, SOCS-5, Cish5
    DNA
    TYPE functioning gene
    STRUCTURE 63.83 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4422 66 536 - 2019 30974024
    2 splicing 4510 66 536 - 2019 30974024
    different 5' utr
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved region of about 70 AAs in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence
  • N-terminal region of SOCS5 coordinates critical protein interactions involved in inhibition of JAK/STAT signaling, and a conserved region within the N-terminus of SOCS5 mediates direct binding to the JAK kinase domain
  • solitary central Src homology SH2 domain
  • a C terminal SOCS, CIS (CH domain) sequence
  • HOMOLOGY
    interspecies ortholog to murine Socs5 (suppressor of cytokine signaling protein 5)
    Homologene
    FAMILY
  • suppressor of cytokine signaling family (SOCS)
  • STAT inducer STAT inhibitory protein family
  • CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibiting cytokine signaling
  • regulating protein turnover, targeting proteins to proteasome mediated degradation
  • potential negative regulator of epidermal growth factor signaling
  • involved in epidermal growth factor-mediated signaling pathways (Kario 2005)
  • different domains in SOCS5 contribute likely to two distinct mechanisms for regulation of cytokine and growth factor signaling
  • SOCS5 mediates the impaired function of Dendritic cells in chronic lymphocytic leukemia patients
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • JAK kinases
  • activated cytokine receptors
  • SOCS5 can directly inhibit JAK1 kinase activity, although its mechanism of action appears distinct from that of SOCS1 and SOCS3
  • can negatively regulate both JAK/STAT and EGF-receptor pathways and has therefore been implicated in regulating both the immune response and tumorigenesis
  • cell & other
    REGULATION
    activated by in response to EGF stimulation
    induced by cytokines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma tissues, compared to adjacent non-tumor liver tissues
    tumoral     --other  
    is epigenetically deregulated in T-ALL
    constitutional     --low  
    significantly down-regulated in multiple sclerosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    inhibition of SOCS5 and mTOR may be a potential therapeutic approach to inhibit hepatocellular carcinoma metastasis and prolong patient survival
    cancerhemopathy 
    having potential to be a new therapeutic target for reversing cancer-associated immune suppression
    ANIMAL & CELL MODELS