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FLASH GENE
Symbol SOCS4 contributors: mct - updated : 17-03-2020
HGNC name suppressor of cytokine signaling 4
HGNC id 19392
Location 14q22.3      Physical location : 55.493.843 - 55.516.204
Synonym name
  • cytokine inducible SH2 protein 7
  • SH2 domain containing SOCS box protein
  • Synonym symbol(s) SOCS, DKFZp686J1568
    DNA
    TYPE functioning gene
    STRUCTURE 22.36 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 6774 50.62 440 - 2015 26437444
    a supplementary exon in the 5' region
    3 splicing 6903 - 440 - 2015 26437444
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Hearing/Equilibriumearinnercochlea highly
    Urinarybladder   highly
     kidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved region of about 70 AAs in the N-terminal domains of SOCS4 and 5 that is predicted to be more ordered than the surrounding sequence
  • one SOCS box domain
  • solitary central Src homology SH2 domain
  • a C terminal SOCS, CIS (CH domain) sequence
  • HOMOLOGY
    intraspecies homolog to SOCS5
    Homologene
    FAMILY SOCS family, STAT inducer STAT inhibitoiy protein faminy
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in intracellular signaling cascade
  • regulate epidermal growth factor receptor signaling
  • is a critical regulator of anti-viral immunity
  • is a known inhibitor of epidermal growth factor (EGF) receptor signalling
  • is dispensable for an efficient recall response to influenza virus infection
  • SOCS3 and SOCS4 appear to play regulatory roles in a number of keratinocyte and endothelial cellular traits associated with the wound healing process
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SOCS4 reduces STAT3 signaling from EGFR through increased receptor degradation
  • CUL5 is a scaffold protein that recruits RNF7, the ELOB/ELOC complex, and SOCS box proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    tumoral     --over  
    significantly associated with earlier tumour stage and better clinical outcome in human breast cancer
    constitutional germinal mutation      
    in autoimmune disorder
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking functional Socs4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs