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FLASH GENE
Symbol SOCS4 contributors: - updated : 06-06-2007
HGNC name suppressor of cytokine signaling 4
HGNC id 19392
Location 14q22.2      Physical location : 55.493.843 - 55.516.204
Synonym name cytokine onducible SH2 protein 7
Synonym symbol(s) SOCS
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 7029 50.62 440 - Kile
a supplementary exon in the 5' region
- splicing 6900 - - - Kile
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Hearing/Equilibriumearinnercochlea highly
Urinarybladder   highly
 kidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SOCS box domain
  • solitary central Src homology SH2 domain
  • a C terminal SOCS, CIS (CH domain) sequence
  • HOMOLOGY
    intraspecies homolog to SOCS5
    Homologene
    FAMILY SOCS family, STAT inducer STAT inhibitoiy protein faminy
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in intracellular signaling cascade
  • regulate epidermal growth factor receptor signaling
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS