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FLASH GENE

Symbol

SOBP

contributors: mct - updated : 02-12-2010

HGNC name	sine oculis binding protein homolog (Drosophila)
HGNC id	29256

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MRAMS mental retardation, anterior maxillary protrusion, and strabismus
Location	6q21      Physical location : 107.811.316 - 107.982.508
Synonym name	jackson circler protein 1
Synonym symbol(s)	RP1-47M23.2, FLJ10159, JXC1

DNA

TYPE	functioning gene
STRUCTURE	171.20 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018013 7 - 6248 NP_060483 92.7 873 - 2010 21035105

EXPRESSION

Rna function	mRNA was detected in inner ear sensory hair cells
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Homo sapiens Nervous brain forebrain cerebral cortex   highly Homo sapiens   brain limbic system     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

Text	in the developing retina, olfactory epithelium, trigeminal ganglion, and hair follicles

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two FCS-type zinc finger domains (PS51024)
	nuclear localization signals
	highly conserved sequence motifs

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

potential role in controlling a critical step in cochlear growth, cell fate, and patterning of the organ of Corti

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRAMS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS