Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SOAT2 contributors: mct - updated : 01-04-2019
HGNC name sterol O-acyltransferase 2
HGNC id 11178
Location 12q13.13      Physical location : 53.497.273 - 53.518.322
Synonym name
  • acyl Co-A: cholesterol acyltransferase 2
  • Synonym symbol(s) ACAT2, ARGP2, ACACT2, MGC116732
    EC.number 2.3.1.26
    DNA
    TYPE functioning gene
    STRUCTURE 21.05 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure lack sterol regulatory elements in the promoter
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2073 - 522 - 2017 28604676
  • variant 1, or ACAT2a
  • - splicing - - 502 - 2017 28604676
  • lack of the exon 4
  • lacked the phosphorylatable site SLLD, and their enzymatic activities reduced to 30p100 of that of ACAT2a
  • - splicing - - 379 - 2017 28604676
  • lack exons 4-5 plus 8-9-10
  • lacked the phosphorylatable site SLLD, and enzymatic activities reduced to 30p100 of that of ACAT2a
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly Homo sapiens
     liver     Homo sapiensFetal
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Soat2
    intraspecies homolog to SOAT2
    Homologene
    FAMILY sterol-o-acyltransferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text located in the rough endoplasmatic reticulum that catalyzes the synthesis of cholesteryl esters from cholesterol and long-chain fatty acids
    basic FUNCTION
  • sterol O-acyltransferase 2, a crucial element of intracellular lipid homeostasis
  • plays an important role in cholesterol absorption
  • esterifies cholesterol in enterocytes and hepatocytes
  • responsible for intracellular cholesterol esterification
  • is the major cholesterol esterifying enzyme in the liver and small intestine (SI)
  • plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia.
  • SOAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters
  • lipid-induced stabilization of SOAT2 ameliorates lipotoxicity from excessive cholesterol and fatty acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TGIF1 functioning as an important repressor of SOAT2
  • cell & other
    REGULATION
    Other transcriptionally regulated by cholesterol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    aberrantly expressed in macrophage and lipid-laden cells of the atheromatous plaques
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    inhibitors of SOAT2 targeting either tissue likely would be beneficial for atheroprotection
    ANIMAL & CELL MODELS
  • deletion of sterol O-acyltransferase 2 (Soat2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver