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FLASH GENE
Symbol SOAT1 contributors: mlc - updated : 02-06-2006
HGNC name sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
HGNC id 11177
Location 1q25      Physical location : 179.263.016 - 179.324.452
Synonym name acyl CoA : cholesterol acyltransferase 1 precursor A
Synonym symbol(s) ACAT, SOAT, STAT, ACACT
EC.number 2.3.1.26
DNA
TYPE functioning gene
STRUCTURE 61.00 kb     16 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure lacking the sterol regulatory elements
MAPPING cloned Y linked   status confirmed
regionally located SOAT1 knockout lice (Meiner,1996)
RNA
TRANSCRIPTS type messenger
text with three alternative forms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 7000
- - 3407 - 550 - Drimal
     - - - -
- - - 2800
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , heteromer , dimer
HOMOLOGY
interspecies homolog to murine Soat1
homolog to rattus Soat1
intraspecies homolog to soat2
Homologene
FAMILY sterol O -acyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
text membrane protein located in the endoplasmic reticulum
basic FUNCTION
  • sterol O-acyltransferase 1, a crucial element of intracellular lipid homeostasis
  • synthesizing esters from cholesterol and long-chain fatty acyl CoA
  • playing a role in lipoprotein assembly dietary cholesterol absorption and atherogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text circulation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid, fatty-acid and sterol metabolism (cholesterol)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by the presence of cholesterol
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    accumulation of insoluble cholesterol esters in macrophages smooth muscle of atherosclerosis lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    SOAT1 knock out mice (Meiner,96)