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FLASH GENE
Symbol SNX9 contributors: mct - updated : 07-11-2014
HGNC name sorting nexin 9
HGNC id 14973
Location 6q25.3      Physical location : 158.244.293 - 158.366.109
Synonym name
  • SH3 and PX domain-containing protein SH3PX1
  • Wiskott-Aldrich syndrome protein (WASP) interactor protein
  • Synonym symbol(s) SDP1, SH3PX1, WISP, MST155, MSTP155, SH3PXD3A
    DNA
    TYPE functioning gene
    STRUCTURE 121.82 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC389437 6 LOC389437 ELD/OSA1 6q25.1 LOC389437 ZDHHC14 6q25.3 zinc finger, DHHC domain containing 14 LOC389438 6 LOC389438 SNX9 6q25.1-q26 sorting nexin 9 SYNJ2 6q25.1-q25.2 synaptojanin 2 SERAC1 6q25.3 serine active site containing 1 LOC153932 6q25.3 signal recognition particle 72kD pseudogene TULP4 6q25.3 tubby like protein 4 TCTEL1 6q25.2-q25.3 t-complex-associated-testis-expressed 1-like 1 SYTL3 6q25.3 synaptotagmin-like 3 VIL2 6q25-q26 villin 2 (ezrin) LOC389439 6 LOC389439 LOC202459 6q25.3 similar to RIKEN cDNA 2310008M10 LOC389440 6 LOC389440 LOC346064 6q25.3 similar to SNARE protein Ykt6; YKT6, S. cerevisiae, homolog of RSHL2 6q25.3 radial spokehead-like 2 TAGAP 6q25.3 T-cell activation GTPase activating protein LOC389441 6 LOC389441 LOC389442 6 LOC389442 LOC389443 6 LOC389443 LOC389444 6 similar to frazzled CG8581-PA FNDC1 6q25 fibronectin type III domain containing 1 LOC389445 6 similar to 60S ribosomal protein L21 SOD2 6q25.2 superoxide dismutase 2, mitochondrial
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4200 - 595 - 2005 1613768
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
     vesselsaorta  highly
    Reproductivemale systemprostate   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines melanoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • N terminal SH3 domains followed by a Phox (pX) homology domains, which is a phosphoinositide binding domain, and are involved in intracellular trafficking
  • a PX-BAR domain (Bin/Amphiphysin/Rvs (BAR) domains), having the capacity to tubulate membranes
  • a C terminal coiled-coil domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Snx9
    intraspecies paralog to SNX18, SNX30
    Homologene
    FAMILY sorting nexin family
    CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    text expressed in the presynaptic compartment of cultured hippocampal neurons, where it binds to dynamin-1 and WASL
    basic FUNCTION
  • involved in several stage of intracellular trafficking
  • regulating dynamin assembly and required for efficient clathrin-mediated endocytosis
  • able to deform the plasma membrane, as well as liposomes, into narrow tubules and recruit WASL and dynamin 2 to these tubules via its SH3 domain
  • functions in the coordination of membrane remodeling and fission via interactions with actin-regulating proteins, endocytic proteins and PtdIns(4,5)P2-metabolizing enzymes
  • through its interactions, SNX9 plays an important role in clathrin-mediated endocytosis in non-neuronal cells
  • primarily acting in clathrin-mediated endocytosis at the plasma membrane
  • has the ability to activate the actin regulator WASL in a membrane-dependent manner to coordinate actin polymerization with vesicle release
  • functions in a complex with the GTPase dynamin-2 at clathrin-coated pits, where it provokes fission of vesicles to complete endocytosis
  • SNX18 has a similar role to SNX9 in endocytic trafficking at the plasma membrane
  • SNX18 functions with SNX9 in multiple pathways of endocytosis at the plasma membrane and that they are functionally redundant
  • SNX9, SNX18 and SNX33 are required for progression and completion of mitosis
  • plays an additional non-endocytic role at early mitotic stages
  • SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes
  • SNX9 and clathrin heavy chain (CLTC) each have roles in mitosis during metaphase
  • SNX9 and CLTC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • can be dimerized, and binds dynamin at one end and WASL at the other, raising the possibility that it links actin dynamics and synaptic vesicle endocytosis
  • SNX18 and SNX9 can form a heterodimer and colocalize in tubular membrane structures
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic domain of metalloprotease disintegrins ADAM9, ADAM15
  • binds strongly to dynamin and is partly responsible for the recruitment of this GTPase to sites of endocytosis
  • CDC42 associated kinase 2 to regulate the degradation of EGFR
  • interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15
  • targets a number of sequences within the proline-rich regions of synaptojanin (SYNJ1)
  • interacts with dynamin-1 and WASL in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis
  • interactions with aldolase are far more extensive and differ from those of the actin-nucleating factor WAS with aldolase, indicating considerable plasticity in mechanisms that direct the functions of the aldolase as a scaffold protein
  • like SNX9, SNX18 interacts with dynamin and stimulates the basal GTPase activity of dynamin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS