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FLASH GENE

Symbol

SNX8

contributors: SGE/npt - updated : 18-01-2010

HGNC name	sorting nexin 8
HGNC id	14972

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p22.3      Physical location : 2.294.640 - 2.354.099
Synonym symbol(s)	Mvp1

DNA

TYPE	functioning gene
STRUCTURE	59.46 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013321 11 - 1522 NP_037453 15.44 465 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one PX domain (phosphoinositide binding domain)

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Snx8 (89.5pc)
	homolog to murine Snx8 (89.5pc)

Homologene

FAMILY

sorting nexin family

CATEGORY

signaling , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION	involved in several stage of intracellular trafficking
	involved in endosomal sorting (Dyve 2009)

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS