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FLASH GENE
Symbol SNX5 contributors: mct/npt - updated : 17-05-2008
HGNC name sorting nexin 5
HGNC id 14969
Location 20p11      Physical location : 17.922.245 - 17.949.490
Synonym name weakly similar to sorting nexin 1
Synonym symbol(s) RP11-504H3.2, FLJ10931
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RPLP0P1 20p11.23 ribosomal protein, large, P0 pseudogene 1 RPL7AL3 20p11.23 ribosomal protein L7a-like 3 SNRPB2 20p12.2-p11.22 small nuclear ribonucleoprotein polypeptide B'' OTOR 20p12.1-p11.23 otoraplin PCSK2 20p11.2 proprotein convertase subtilisin/kexin type 2 BFSP1 20p11.23 beaded filament structural protein 1, filensin RPS27AP2 20p11.2 ribosomal protein S27a pseudogene 2 DSTN 20p11.23 destrin (actin depolymerizing factor) RRBP1 20p12-p11.2 ribosome binding protein 1 homolog 180kDa (dog) C20orf179 20 chromosome 20 open reading frame 179 SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae) LOC388789 20 hypothetical gene supported by AF147354 HARS2 20p11.23 histidyl-tRNA synthetase 2 HSPC072 20p11.23 HSPC072 protein C20orf78 20p11.23 chromosome 20 open reading frame 78 C20orf79 20 chromosome 20 open reading frame 79 SLC24A3 20p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
RNA
TRANSCRIPTS type messenger
text alternative spliced transcripts 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2154 46.8 404 - Wassmer (2007)
13 - 2058 46.8 404 - Wassmer (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines cancer cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a phosphoinositide-binding Phox homology (PX) domain, characteristic of SNX family
  • HOMOLOGY
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • colocalised with SNX1 and SNX6 on early endosomes
  • colocalized with DOCK1 at endosomes
  • basic FUNCTION
  • involved in receptor trafficking between organelles
  • may have functions not only associated with endosomal sorting but also with the phosphoinositide-signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    phosphoinositide-signaling pathway
    a component
  • components of the mammalian retromer (a multimeric protein complex involved in mediating endosome-to-trans-Golgi-network retrograde transport of the cation-independent mannose-6-phosphate receptor)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FANCA binding
  • receptor tyrosine kinases
  • VIMP can interact with CKAP4 and SNX5, it does not interact with MT-binding ER proteins (such as REEP1) that shape the tubular smooth ER
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS