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FLASH GENE
Symbol SNX4 contributors: mct/npt - updated : 21-11-2014
HGNC name sorting nexin 4
HGNC id 11175
Location 3q21.2      Physical location : 125.165.494 - 125.239.058
Synonym symbol(s) ATG24B
DNA
TYPE functioning gene
STRUCTURE 73.56 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2567 51 450 - 2003 12668730
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Nervousbrain   moderately
Reproductivefemale systemplacenta  highly
 male systemprostate  highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
physiological period fetal, pregnancy
Text highly in umbilical cord and placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a Phox homology domain (PX)
  • a Bin-Amphiphysin-Rvs (BAR) domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to rattus Snx4 (94.2 pc)
    homolog to murine Snx4 (94 pc)
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text through its phox homology (PX) and Bin-Amphiphysin-Rvs (BAR) domains, sorting nexin-4 (SNX4) is associated with tubular and vesicular elements of a compartment that overlaps with peripheral early endosomes and the juxtanuclear endocytic recycling compartment (ERC) (Traer 2007)
    basic FUNCTION
  • involved in several stage of intacellular trafficking
  • coordinates iterative, geometric-based sorting of TFRC with the long-range transport of carriers from early endosomes to the endocytic recycling compartment (Traer 2007)
  • is involved in the recycling of TFRC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homo, hetero oligomers with SNX1, SNX2, SNX3, SNX15
  • forms complexes with clathrin and dynein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF receptor (EGFR),platelets derived growth factor receptors (PDGFRA,PDGFRB),insulin receptor (INSR)
  • through an interaction with WWC1, SNX4 associates with the minus end-directed microtubule motor dynein (Traer 2007)
  • upon clathrin release, dynein may bind SNX4 and mediate retrograde movement
  • is associated with the RAB11A-recycling endosomes and a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo RAB4A-to-RAB11A transition
  • FLOT2 directly interacts with RAB11A and SNX4
  • TXLNA interacts with SNX4 and plays a role in the recycling pathway of TFRC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS