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FLASH GENE
Symbol SNX4 contributors: mct/npt - updated : 21-11-2014
HGNC name sorting nexin 4
HGNC id 11175
Location 3q21.2      Physical location : 125.165.494 - 125.239.058
Synonym symbol(s) ATG24B
DNA
TYPE functioning gene
STRUCTURE 73.56 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
TRAD 3q21.2 serine/threonine kinase with Dbl- and pleckstrin homology domains UMPS 3q13 uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) ITGB5 3q21.2 integrin, beta 5 MUC13 3q13.3 mucin 13, epithelial transmembrane HEG 3q21.2 HEG homolog SLC12A8 3q21 solute carrier family 12 (potassium/chloride transporters), member 8 ZNF148 3q21 zinc finger protein 148 (pHZ-52) SNX4 3q21.1-q21.3 sorting nexin 4 OSBPL11 3q21 oxysterol binding protein-like 11 LOC389144 3 similar to seven transmembrane helix receptor OR7E93P 3q13.33 olfactory receptor, family 7, subfamily E, member 93 pseudogene OR7E53P 3q13.33 olfactory receptor, family 7, subfamily E, member 53 pseudogene OR7E97P 3q13.33 olfactory receptor, family 7, subfamily E, member 97 pseudogene LOC344729 3q21.2 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC389145 3 LOC389145 LOC165622 3q21.2 similar to Alkaline sphingomyelinase LOC200810 3q21.2 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase LOC152015 3q21.2 similar to AKAP-binding sperm protein ropporin FLJ20473 FTHFD 3q21.2 formyltetrahydrofolate dehydrogenase KLF15 3q13-q21 Kruppel-like factor 15 FLJ40083 3q21.3 hypothetical protein FLJ40083 FLJ20123 3q21.3 hypothetical protein FLJ20123 MGC11349 3q21.3 hypothetical protein MGC11349 FLJ31300 3q21.3 hypothetical protein FLJ31300 CHST13 3q21.3 carbohydrate (chondroitin 4) sulfotransferase 13 MGC34728 3q21.3 hypothetical protein MGC34728 TXNRD3 3p13-q13.33 thioredoxin reductase 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2567 51 450 - 2003 12668730
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Nervousbrain   moderately
Reproductivefemale systemplacenta  highly
 male systemprostate  highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  moderately
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
physiological period fetal, pregnancy
Text highly in umbilical cord and placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a Phox homology domain (PX)
  • a Bin-Amphiphysin-Rvs (BAR) domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to rattus Snx4 (94.2 pc)
    homolog to murine Snx4 (94 pc)
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text through its phox homology (PX) and Bin-Amphiphysin-Rvs (BAR) domains, sorting nexin-4 (SNX4) is associated with tubular and vesicular elements of a compartment that overlaps with peripheral early endosomes and the juxtanuclear endocytic recycling compartment (ERC) (Traer 2007)
    basic FUNCTION
  • involved in several stage of intacellular trafficking
  • coordinates iterative, geometric-based sorting of TFRC with the long-range transport of carriers from early endosomes to the endocytic recycling compartment (Traer 2007)
  • is involved in the recycling of TFRC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homo, hetero oligomers with SNX1, SNX2, SNX3, SNX15
  • forms complexes with clathrin and dynein
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF receptor (EGFR),platelets derived growth factor receptors (PDGFRA,PDGFRB),insulin receptor (INSR)
  • through an interaction with WWC1, SNX4 associates with the minus end-directed microtubule motor dynein (Traer 2007)
  • upon clathrin release, dynein may bind SNX4 and mediate retrograde movement
  • is associated with the RAB11A-recycling endosomes and a high frequency of SNX4-mediated tubule formation is observed as endosomes undergo RAB4A-to-RAB11A transition
  • FLOT2 directly interacts with RAB11A and SNX4
  • TXLNA interacts with SNX4 and plays a role in the recycling pathway of TFRC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS