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FLASH GENE
Symbol SNX27 contributors: mct - updated : 12-03-2016
HGNC name sorting nexin family member 27
HGNC id 20073
Location 1q21.3      Physical location : 151.584.661 - 151.671.559
Synonym name
  • methamphetamine-responsive transcript 1
  • Synonym symbol(s) MY014, KIAA0488, MRT1
    DNA
    TYPE functioning gene
    STRUCTURE 86.90 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 7085 62 528 - 2011 21926430
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouth   moderately
    Endocrineadrenal gland   highly
     neuroendocrinepituitary  highly
    Reproductivefemale systemplacenta  moderately
     female systembreastmammary gland moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly
    Connectivebone  moderately
    Muscular   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a functional PX (phox homology) domain, important for endosome binding, but it is the only sorting nexin with a PDZ domain
  • a Ras association domain
  • a PDZ domain
  • a phospholipid-binding motif 0)
  • HOMOLOGY
    interspecies homolog to rattus Snx27 (98.7 pc)
    homolog to murine Snx27 (98.9 pc)
    Homologene
    FAMILY sorting nexin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • localized to early endosomes
  • localized to both the early endosome and the plasma membrane 0)
  • basic FUNCTION
  • involved in several stages of intracellular trafficking
  • likely recruits PSCDBP to endosomal membranes where they may participate in coordinating vesicular traffic and/or signaling complexes
  • polarizes to the apical membrane in NK cell migration and during formation of the immunological synapse
  • being likely either a target of the polarizing machinery or possibly even a mediator of the mechanism directly
  • regulating the trafficking of Kir3 channels
  • being important for trafficking to the early endosome
  • promoting the endosomal movement of Kir3 channels, leading to reduced surface expression, increased degradation and smaller Kir3 potassium currents
  • required for efficient PDZ-directed recycling of ADRB2 from early endosomes
  • role of SNX27 in PDZ-directed recycling of a physiologically important signaling receptor
  • plays an essential role in postnatal growth and survival
  • may function to regulate endocytosis and/or endosomal sorting of NR2C)
  • participate in vesicular and protein trafficking
  • PDZ-containing component of the T cell immunological synapse, playing a role in the regulation of the Ras-ERK pathway
  • serves as an essential adaptor protein linking ADRB2 to the retromer tubule (
  • regulates trafficking of ARHGEF7 to focal adhesions and thereby influences cell motility
  • mediates ABCC4 internalization and thereby negatively modulates the cell surface expression and transport function of ABCC4
  • role for SNX27 in glutamine uptake and amino acid-stimulated MTOR activation via modulation of SLC1A5 intracellular trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PSCDBP (co-localize at the early endosomal compartment in lymphocytes)
  • GRIN2C is a novel SNX27-interacting protein, and this interaction is mediated by the PDZ domain of SNX27 and the C-terminal PDZ-binding motif of GRIN2C
  • partner of DGKZ, a negative regulator of T cell function that metabolises diacylglycerol to yield phosphatidic acid
  • does not seem to directly interact with the retromer core complex, but does interact with the retromer-associated Wiskott-Aldrich syndrome protein and SCAR homologue (WASH1) complex
  • SNX27 is the interacting PDZ adaptor protein with a PDZ-binding motif of ABCC4
  • ADRB1 recycles via a membranous organelle, recycling endosome, by binding with SNX27
  • SNX27-TJP2 interaction requires the PDZ domain of SNX27 and the C-terminal PDZ-binding motif of TJP2 (role for SNX27-TJP2 interactions in tight junction maintenance and function)
  • SLC1A5 is a membrane-trafficked cargo molecule, sorted through a direct interaction with the PDZ domain of sorting nexin 27 (SNX27)
  • cell & other
  • binding to phosphoinositide
  • selectively binding to the membrane phospholipid phosphatidylinositol-3-phosphate (PI3P)
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS