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FLASH GENE
Symbol SNX20 contributors: mct/npt - updated : 01-03-2010
HGNC name sorting nexin 20
HGNC id 30390
Location 16q12.1      Physical location : 50.700.210 - 50.715.264
Synonym name selectin ligand interactor cytoplasmic 1
Synonym symbol(s) SLIC-1, SLIC1, MGC35578
DNA
TYPE functioning gene
STRUCTURE 8.38 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2197 - 102 - 2008 1819651
4 - 3304 - 129 - 2008 1819651
4 - 1555 - 316 - 2008 1819651
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver    
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a proline-rich N terminus
  • three potential SH3 domain-interacting PxxP motifs
  • a central phox homology (PX) domain
  • a Phox homology domain that binds phosphoinositides and targets the SELPLG/SNX20 complex to endosomes (Schaff 2008)
  • HOMOLOGY
    interspecies ortholog to mouse sorting nexin 20
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    basic FUNCTION
  • serves as a sorting molecule that cycles SELPLG into endosomes with no impact on leukocyte recruitment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction between SNX20 and SELPLG was specific
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS