Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SNX2 contributors: mct - updated : 16-09-2015
HGNC name sorting nexin 2
HGNC id 11173
Location 5q23.2      Physical location : 122.110.749 - 122.165.800
Synonym name
  • transformation-related gene 9 protein
  • Synonym symbol(s) TRG-9, MGC5204
    DNA
    TYPE functioning gene
    STRUCTURE 59.54 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ33977 5q23.1 hypothetical protein FLJ33977 PTMAP2 5 prothymosin, alpha pseudogene 2 (gene sequence 32) LOC391822 5 similar to chromosome 20 open reading frame 147 DMXL1 5q22 Dmx-like 1 GG2-1 LOC389318 5 LOC389318 HSD17B4 5q2 hydroxysteroid (17-beta) dehydrogenase 4 LOC391823 5 similar to 60S RIBOSOMAL PROTEIN L21 LOC340069 5q23.2 hypothetical protein LOC340069 LOC391824 5 similar to tubulin, alpha 6; tubulin alpha 6 LOC348958 5q23.2 mitochondrial ribosomal protein L10 pseudogene LOC51334 5q23.2 mesenchymal stem cell protein DSC54 LOC391825 5 similar to 60S ribosomal protein L23a LOC256233 5q23.2 similar to ribosomal protein L18; 60S ribosomal protein L18 MTF  mitochondrial ferritin FLJ25286 5q23.2 hypothetical protein FLJ25286 LOX 5q23.3-q31.2 lysyl oxidase LOC133923 5q23.2 similar to RIKEN cDNA 4933409D10 LOC153441 5q23.2 similar to RIKEN cDNA 4933409D10 SNCAIP 5q23.1-q23.3 synuclein, alpha interacting protein (synphilin) SNX2 5q23 sorting nexin 2 SNX24 5q23.2 sorting nexing 24 PPIC 5q23.2 peptidylprolyl isomerase C (cyclophilin C) PRDM6 5q21-q23 PR domain containing 6 LOC391826 5 similar to Ubiquitin-like protein SMT3C precursor (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein UBL1) (Ubiquitin-related protein SUMO-1) (GAP modifying protein 1) (GMP1) (Sentrin) FLJ36090 5q23.2 hypothetical protein FLJ36090 CSNK1G3 5q23 casein kinase 1, gamma 3 LOC391827 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) KIAA1281 5q23.2 KIAA1281 protein LOC391828 5 similar to ribosomal protein L28 LOC391829 5 similar to High mobility group protein 1-like 10 (HMG-1L10) LOC389319 5 LOC389319 NS3TP2 5q23.3 HCV NS3-transactivated protein 2 ALDH7A1 5q31 aldehyde dehydrogenase 7 family, member A1 PHAX 5q23.3 likely ortholog of mouse phosphorylated adaptor for RNA export LOC133609 5q23.3 similar to 60S acidic ribosomal protein P1 LOC389320 5 hypothetical gene supported by AK131015 LOC285008 5q23.3 hypothetical gene supported by BC028282; BC028282; BC028282 LMNB1 5q23.3-q31.1 lamin B1 LOC389321 5 LOC389321 MGC48332 5q23.3 hypothetical protein MGC48332
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 7110 - 402 - 2000 11102511
    15 - 6559 - 519 highly in spleen, heart, skeletal muscle and leukocytes, low in liver kidney and brain 2000 11102511
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid     Homo sapiens
    Skin/Tegumentskin    
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrinethyroid cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • one phox homology domain (PX)
  • mono polymer homomer , heteromer , polymer , complex
    HOMOLOGY
    interspecies ortholog to murine Snx2
    intraspecies homolog to with SNX1
    Homologene
    FAMILY sorting nexins family
    CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • playing a role in intracellular trafficking of the cells and EGFR signaling pathway
  • SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function
  • SNX1 and SNX2 interact directly with inactive RHOG, suggesting a novel role for these SNX proteins in recruiting an inactive Rho GTPase to its exchange factor
  • SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of growth factor receptors including epidermal growth factor receptor (EGFR) and MET
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homo, hetero oligomers with SNX1, SNX3, SNX4, SNX15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF receptor (EGFR), platelets derived growth factor receptors (PDGFRA,PDGFRB),insulin receptor (INSR)
  • FBP17
  • SNX1 and SNX2 interact with the RAC1 and RHOG guanine nucleotide exchange factor KALRN
  • BLOC1S1 interacted with SNX2 (a retromer subunit) and TSG101 (an endosomal sorting complex required for transport subunit-I) to mediate EGFR lysosomal trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), arising from a t(5;9)(q22;q34) translocation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • utility of SNX2 as a novel marker of active thyrocytes and reflect the endosomal trafficking activity in these cells
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    development of drugs targeting SNX2 could be useful in overcoming drug resistance to EGFR-targeted drugs in lung cancer cells harboring c-Met gene amplification
    ANIMAL & CELL MODELS