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FLASH GENE
Symbol SNX2 contributors: mct - updated : 16-09-2015
HGNC name sorting nexin 2
HGNC id 11173
Location 5q23.2      Physical location : 122.110.749 - 122.165.800
Synonym name
  • transformation-related gene 9 protein
  • Synonym symbol(s) TRG-9, MGC5204
    DNA
    TYPE functioning gene
    STRUCTURE 59.54 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 7110 - 402 - 2000 11102511
    15 - 6559 - 519 highly in spleen, heart, skeletal muscle and leukocytes, low in liver kidney and brain 2000 11102511
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid     Homo sapiens
    Skin/Tegumentskin    
    Urinarybladder    
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrinethyroid cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • one phox homology domain (PX)
  • mono polymer homomer , heteromer , polymer , complex
    HOMOLOGY
    interspecies ortholog to murine Snx2
    intraspecies homolog to with SNX1
    Homologene
    FAMILY sorting nexins family
    CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • playing a role in intracellular trafficking of the cells and EGFR signaling pathway
  • SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function
  • SNX1 and SNX2 interact directly with inactive RHOG, suggesting a novel role for these SNX proteins in recruiting an inactive Rho GTPase to its exchange factor
  • SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of growth factor receptors including epidermal growth factor receptor (EGFR) and MET
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homo, hetero oligomers with SNX1, SNX3, SNX4, SNX15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF receptor (EGFR), platelets derived growth factor receptors (PDGFRA,PDGFRB),insulin receptor (INSR)
  • FBP17
  • SNX1 and SNX2 interact with the RAC1 and RHOG guanine nucleotide exchange factor KALRN
  • BLOC1S1 interacted with SNX2 (a retromer subunit) and TSG101 (an endosomal sorting complex required for transport subunit-I) to mediate EGFR lysosomal trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion gene SNX2-ABL1 in a pediatric case of acute lymphoblastic leukemia (ALL), arising from a t(5;9)(q22;q34) translocation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • utility of SNX2 as a novel marker of active thyrocytes and reflect the endosomal trafficking activity in these cells
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    development of drugs targeting SNX2 could be useful in overcoming drug resistance to EGFR-targeted drugs in lung cancer cells harboring c-Met gene amplification
    ANIMAL & CELL MODELS