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FLASH GENE
Symbol SNX18 contributors: npt/mct - updated : 07-11-2012
HGNC name sorting nexin 18
HGNC id 19245
Location 5q11.2      Physical location : 53.813.588 - 53.842.415
Synonym name
  • sorting nexin associated golgi protein 1
  • SH3 and PX domain-containing protein 3B
  • Synonym symbol(s) SNAG1, SH3PX2, SH3PXD3B, FLJ11997, FLJ32560, MGC150827, MGC150829
    DNA
    TYPE functioning gene
    STRUCTURE 28.83 kb     2 Exon(s)
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5238 - 624 - 2010 20427313
    1 - 3259 68 628 - 2010 20427313
    2 - 5382 - 591 - 2010 20427313
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousspinal cordanterior horn    Homo sapiens
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • expressed in in embryonic spinal motor neurons transient and downregulated as the neurons matured
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PX-BAR domain, having the capacity to tubulate membranes
  • a gamma-adaptin recognition motif
  • HOMOLOGY
    intraspecies paralog to SNX30, SNX9
    Homologene
    FAMILY
  • sorting nexin family, SNX 9 subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text localized to AP-1- and PACS1-positive endosomal structures
    basic FUNCTION
  • mediates budding of carriers for AP-1-positive endosomal trafficking
  • has a similar role to SNX9 in endocytic trafficking at the plasma membrane
  • SNX18 functions with SNX9 in multiple pathways of endocytosis at the plasma membrane and that they are functionally redundant
  • SNX9, SNX18 and SNX3 are required for progression and completion of mitosis
  • SNX9 subfamily members are required for mitosis through both endocytosis-dependent and -independent processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SNX18 and SNX9 can form a heterodimer and colocalize in tubular membrane structures
  • RAB11 FIP5-SNX18 complex plays a pivotal role in the polarized transport of apical proteins during apical lumen initiation in epithelial cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • like SNX9, SNX18 interacts with dynamin and stimulates the basal GTPase activity of dynamin
  • SNX18 is a novel RAB11FIP5-interacting protein, having a role both in epithelial lumen morphogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS