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FLASH GENE
Symbol SNX1 contributors: mct - updated : 15-09-2015
HGNC name sorting nexin 1
HGNC id 11172
Location 15q22.31      Physical location : 64.388.176 - 64.436.431
Synonym name
  • vacuolar protein sorting 5 (yeast homolog)
  • sorting nexin 1A
  • Synonym symbol(s) VPS5, SNX1A, HsT17379, MGC8664
    DNA
    TYPE functioning gene
    STRUCTURE 50.16 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site
    text structure Sp1 and E2F binding sites
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 8332 - 522 - 2001 11410165
    13 splicing 8137 - 457 - 2001 11410165
    missing an internal segment compared to isoform a
    - - 8077 - 474 - 2001 11410165
    lacks an in-frame segment of the coding region, compared to variant 1
    15 - 7858 - 557 - 2001 11410165
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     thyroid   highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • PHOX homology domain (PX) containing a polyproline motif, typical of SH3 domain binding protein
  • a BAR domain
  • mono polymer homomer , heteromer , polymer
    HOMOLOGY
    interspecies homolog to murine Snx1
    Homologene
    FAMILY sorting nexin family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • partial colocalization of PSD and SNX1 in the dendritic fields of the hippocampus
  • basic FUNCTION
  • sorting the internalized receptors from endosome to lysosome
  • essential role for endogenous SNX1 in sorting activated PAR1 to a distinct lysosomal degradative pathway that is independent of retromer, HARS, and TSG101
  • SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function
  • role for SNX1 in retrieval of CDH1 from a degradative endosomal pathway and in membrane trafficking pathways that regulate CDH1 recycling
  • regulate the endosomal sorting of cell surface receptors either to lysosomes where they are downregulated or back to the cell surface
  • novel function of SNX1 in the regulation of P2Y(1) receptor recycling and suggest that SNX1 plays multiple roles in endocytic trafficking of GPCRs
  • SNX1 and SNX2 interact directly with inactive RHOG, suggesting a novel role for these SNX proteins in recruiting an inactive Rho GTPase to its exchange factor
  • crucial role for SNX1 in DRD5 trafficking and SNX1 depletion results in DRD5 dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
  • SNX1 and SNX2 are components of the mammalian retromer complex and they also play critical roles in the membrane trafficking of growth factor receptors including epidermal growth factor receptor (EGFR) and MET
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • homo, hetero oligomers with SNX2, SNX3, SNX4, SNX5
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EGF receptors (EGFP), platelets derived growth factor receptors (PDGFRA, PDGFRB), insulin recptor (INSR), leptin receptor (LEPR), long form
  • HGS interacts with SNX1 and regulates degradation of epidermal growth factor receptor, but also via the core complex component VPS35
  • SNX1 and SNX2 interact with the RAC1 and RHOG guanine nucleotide exchange factor KLRN
  • DENND5A interacting with SNX1
  • retromer component that is implicated in endosomal sorting and trafficking, and is a novel interacting partner for PSD
  • PSD regulates ARF6-mediated neurite formation through the interaction with SNX1
  • GOPC colocalizes with SNX1 and the internalized ADRB1 and protects endocytosed receptors from lysosomal degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS