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FLASH GENE
Symbol SNW1 contributors: mct - updated : 25-02-2011
HGNC name SNW domain containing 1
HGNC id 16696
Location 14q24.3      Physical location : 78.183.945 - 78.227.497
Synonym name
  • nuclear receptor coactivator 62kDa
  • SKI interacting protein
  • Synonym symbol(s) SKIP, NCOA-62, Bx42, PRPF45, Prp45, SKIIP
    DNA
    TYPE functioning gene
    STRUCTURE 43.55 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388000 14 LOC388000 KIAA1036 14q24.3 LOC388000 KIAA0759 14q24.3 LOC388000 LOC145497 14q24.3 hypothetical protein LOC145497 RPL22P2 14 ribosomal protein L22 pseudogene 2 RPLP1P1 14q23 ribosomal protein, large, P1 pseudogene 1 C14orf4 14q24.3 chromosome 14 open reading frame 4 KIAA1737 14q24.3 KIAA1737 C14orf59 14 chromosome 14 open reading frame 59 C14orf171 14q24.3 chromosome 14 open reading frame 171 NGB 14q24 neuroglobin POMT2 14q24.3 protein-O-mannosyltransferase 2 GSTZ1 14q24.3 glutathione transferase zeta 1 (maleylacetoacetate isomerase) LOC283578 14q24.3 hypothetical protein LOC283578 LOC161394 14q24.3 hypothetical protein LOC161394 LOC122945 14q24.3 hypothetical protein FLJ32809 C14orf133 14q24.3-q31 chromosome 14 open reading frame 133 AHSA1 14q23.3-31 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) THSD3 14q24.3 thrombospondin, type I domain-containing 3 SPTLC2 14q24.3-q31 serine palmitoyltransferase, long chain base subunit 2 ALKBH 14q24 alkB, alkylation repair homolog (E. coli) RPL21P10 14 ribosomal protein L21 pseudogene 10 DC50 14q24.3 hypothetical protein DC50 SNW1 14q24.3 hypothetical protein DC50 FLJ25976 14q24.3 hypothetical protein FLJ25976 ADCK1 14q24.3 aarF domain containing kinase 1 FRDAP 14q24.3 Friedreich ataxia pseudogene NRXN3 14q24.3-q31.1 neurexin 3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2146 - 536 - 2006 16595688
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SH2-like domain
  • a highly flexible region SKIPN, AAs 59-129 is intrinsically disordered, and upon binding to PPIL1, SKIPN undergoes a disorder-order transition
  • HOMOLOGY
    interspecies homolog to Drosophila bx42
    homolog to murine Skiip
    Homologene
    FAMILY SNW family
    CATEGORY regulatory , transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text colocalized with PABP2
    basic FUNCTION
  • coactivator, enhancing transcription from some Pol II promoters (vitamine D, retinoid acid, estrogen and glucocorticoid-mediated gene expression)
  • binding PABP2 and directly controling the expression of muscle-specific genes at the transcriptional level
  • may be involved in oncogenesis
  • plays independent roles in transcription elongation and pre-mRNA splicing
  • modifying gene expression by both transcriptional activation and regulation of pre-mRNA splicing
  • acts with MYC and MEN1 to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress
  • recruits PPIL1 into the spliceosome by a region other than the peptidylprolyl isomerase active site
  • CELLULAR PROCESS nucleotide, transcription, regulation
    nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand-binding domain of the vitamine D receptor
  • retinoid receptors
  • poly (A)-binding protein 2 (PABP2)
  • interacting with PPIL1 (PPIL1-SKIP complex acting during activation of the spliceosome, through PPIL1-binding fragment (PBF)
  • SKI (protooncogene)-(viral and cellular human)
  • MYOD
  • interacting with SMAD3
  • FOXN3/SNW1 interaction indicates that FOXN3 binds to a region within the final 66 hydrophobic AAs of SNW1 (FOXN3 recruits SNW1 to repress genes important for tumorigenesis and the response to cancer treatments)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS